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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Cardiovascular autonomic dysfunction in primary ovarian insufficiency: clinical and experimental evidence

Texto completo
Autor(es):
Goldmeier, Silvia [1] ; De Angelis, Katia [2] ; Casali, Karina Rabello [1] ; Vilodre, Cesar [3] ; Consolim-Colombo, Fernanda [4] ; Klein, Adriane Bello [5] ; Plentz, Rodrigo [6] ; Spritzer, PoliMara [3, 5] ; Irigoyen, Maria-Claudia [1, 4]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Fundacao Univ Cardiol IC FUC, Inst Cardiol Rio Grande Sul, Porto Alegre, RS - Brazil
[2] Univ Nove Julho UNINOVE, Sao Paulo - Brazil
[3] HCPA, Gynecol Endocrinol Unit, Div Endocrinol, Porto Alegre, RS - Brazil
[4] Univ Sao Paulo, Sch Med, Heart Inst InCor, Hypertens Unit, Sao Paulo - Brazil
[5] Univ Fed Rio Grande do Sul, Dept Physiol, Porto Alegre, RS - Brazil
[6] UFCSPA, Dept Physiotherapy, Porto Alegre, RS - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH; v. 6, n. 1, p. 91-101, 2014.
Citações Web of Science: 4
Resumo

Objective: Women with primary ovarian insufficiency (POI) present an increased risk for cardiovascular disease. In this study we tested the hypothesis that POI in women under hormone therapy (HT) are associated with vascular vasodilatation attenuation and cardiovascular autonomic dysfunction and these impairments are related to changes in systemic antioxidant enzymes. Furthermore, the possibility that ovarian hormone deprivation can induce such changes and that HT cannot reverse all of those impairments was examined in an experimental model of POI. Methods: Fifteen control and 17 patients with primary ovarian insufficiency receiving HT were included in the study. To test the systemic and cardiac consequences of ovarian hormone deprivation, ovariectomy was induced in young female rats that were submitted or not to HT. Spectral analysis of RR interval and blood pressure signals were performed and oxidative stress parameters were determined. Results: POI women under HT have increased mean arterial pressure (94 +/- 10 vs. 86 +/- 5 mmHg) despite normal endothelial and autonomic modulation of vasculature. Additionally, they presented impaired baroreflex sensitivity (3.9 +/- 1.38 vs. 7.15 +/- 3.62 ms/mmHg) and reduced heart rate variability (2310 +/- 1173 vs. 3754 +/- 1921 ms(2)). Similar results obtained in ovariectomized female rats were accompanied by an increased lipoperoxidation (7433 +/- 1010 vs. 6180 +/- 289 cps/mg protein) and decreased antioxidant enzymes in cardiac tissue. As it was observed in women, the HT in animals did not restore hemodynamic and autonomic dysfunctions. Conclusion: These data provide clinical and experimental evidence that long term HT may not restore all cardiovascular risk factors associated with ovarian hormone deprivation. (AU)

Processo FAPESP: 12/20141-5 - Efeitos do treinamento físico aeróbio, resistido ou combinado em modelos experimentais de disfunções cardiometabólicas associadas à privação dos hormônios ovarianos
Beneficiário:Kátia de Angelis Lobo D Avila
Modalidade de apoio: Auxílio à Pesquisa - Regular