Treatment of experimental periodontitis in rats using repeated adjunctive antimicrobial photodynamic therapy

Autor(es)

Garcia, Valdir Gouveia ^[1] ; Longo, Mariellen ^[2] ; Fernandes, Leandro Araujo ^[3] ; Gualberto Junior, Erivan Clementino ^[4] ; Santinoni, Carolina dos Santos ^[5] ; Bosco, Alvaro Francisco ^[6] ; Hitomi Nagata, Maria Jose ^[7] ; Theodoro, Leticia Helena ^[8]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP. GEPLO Grp Study & Res Lasers Dent

^[2] Sao Paulo State Univ UNESP. GEPLO Grp Study & Res Lasers Dent

^[3] Sao Paulo State Univ UNESP. GEPLO Grp Study & Res Lasers Dent

^[4] Sao Paulo State Univ UNESP. GEPLO Grp Study & Res Lasers Dent

^[5] Sao Paulo State Univ UNESP. GEPLO Grp Study & Res Lasers Dent

^[6] Sao Paulo State Univ UNESP. GEPLO Grp Study & Res Lasers Dent

^[7] Sao Paulo State Univ UNESP. GEPLO Grp Study & Res Lasers Dent

^[8] Sao Paulo State Univ UNESP. GEPLO Grp Study & Res Lasers Dent

• Tipo de documento: Artigo Científico
• Fonte: Lasers in Medical Science; v. 28, n. 1, p. 143-150, JAN 2013.
• Citações Web of Science: 2

Resumo

The aim of this study was to histologically and histometrically evaluate the influence of repeated adjunctive antimicrobial photodynamic therapy (aPDT) on bone loss (BL) in furcation areas in rats. Periodontitis was induced by placing a ligature around the mandibular molar in 75 rats. The animals were divided into five groups: the SS group was treated with saline solution (SS); the SRP group received scaling and root planing (SRP); the aPDT1 group received SRP as well as toluidine blue (TBO) and low-level laser therapy (LLLT; InGaAlP, 660 nm; 4.94 J/cm(2)/point) postoperatively at 0 h; the aPDT2 group received SRP as well as TBO and LLLT postoperatively at 0, 24, 28, and 72 h; and the aPDT3 group received SRP, TBO, and LLLT postoperatively at 0, 48, 96, and 144 h. The area of BL in the furcation region of the molar was histometrically analyzed. Data were analyzed statistically (P < 0.05). Animals treated with a single episode of aPDT showed less BL at days 7 and 30 than those who received only SRP treatment. No significant differences were found among the aPDT groups (P > 0.05). Repeated aPDT did not improve BL reduction when compared to a single episode of aPDT. (AU)

• Processo FAPESP: 08/10821-3 - Efeitos de diferentes Protocolos de aplicaçao da Terapia Fotodinâmica no tratamento da Doença Periodontal Induzida em ratos:estudo histológico e histométrico
• Beneficiário: Mariéllen Longo
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica