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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Biocompatibility of Portland cement combined with different radiopacifying agents

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Autor(es):
Lourenco Neto, Natalino [1] ; Marques, Nadia C. T. [1] ; Fernandes, Ana Paula [1] ; Rodini, Camila O. [2] ; Duarte, Marco A. H. [3] ; Lima, Marta C. [4] ; Machado, Maria A. A. M. [1] ; Abdo, Ruy C. C. [1] ; Oliveira, Thais M. [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Bauru Sch Dent, Dept Pediat Dent Orthodont & Publ Hlth, Bauru, SP - Brazil
[2] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Bauru, SP - Brazil
[3] Univ Sao Paulo, Bauru Sch Dent, Dept Operat Dent Endodont & Dent, Bauru, SP - Brazil
[4] Univ Toronto, Fac Dent, Matrix Dynam Grp, Toronto, ON - Canada
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF ORAL SCIENCE; v. 56, n. 1, p. 29-34, MAR 2014.
Citações Web of Science: 6
Resumo

The aim of this study was to evaluate the response of rat subcutaneous tissue to Portland cement combined with two different radiopacifying agents, iodoform (CHI3) and zirconium oxide (ZrO2). These materials were placed in polyethylene tubes and implanted into the dorsal connective tissue of Wistar rats for 7 and 15 days. The specimens were then stained with hematoxylin and eosin, and inflammatory reaction parameters were evaluated by light microscopy. The intensity of the inflammatory response to the sealants was analyzed by two blind calibrated observers throughout the experimental period. Histological analysis showed that all the materials caused a moderated inflammatory reaction at 7 days, which then diminished with time. At 15 days, the inflammatory reaction was almost absent, and fibroblasts and collagen fibers were observed indicating normal tissue healing. The degrees of the inflammatory reaction on different days throughout the experimental period were compared using the non-parametric Kruskal-Wallis test. Statistical analysis demonstrated no significant differences amongst the groups, and Portland cement associated with radiopacifying agents gave satisfactory results. Therefore, Portland cement used in combination with radiopacifying agents can be considered a biocompatible material. Although our results are very encouraging, further studies are needed in order to establish safe clinical indications for Portland cement combined with radiopacifying agents. (AU)

Processo FAPESP: 09/11284-4 - Fator de crescimento endotelial vascular na reposta pulpar após o uso de material capeador precedido por anti-inflamatório ou laser de baixa intensidade em pulpotomias de dentes decíduos humanos
Beneficiário:Thais Marchini de Oliveira Valarelli
Linha de fomento: Auxílio à Pesquisa - Regular