| Texto completo | |
| Autor(es): |
Kossuga, Miriam H.
[1]
;
Lira, Simone P.
[1]
;
McHugh, Shayna
[1]
;
Torres, Yohandra R.
[1, 2]
;
Lima, Bruna A.
[3]
;
Goncalves, Reginaldo
[3]
;
Veloso, Katyuscya
[4]
;
Ferreira, Antonio G.
[4]
;
Rocha, Rosana M.
[5]
;
Berlinck, Roberto G. S.
[1]
Número total de Autores: 10
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Estadual, Dept Quim, Ctr Oeste, BR-85040080 Guarapuava, PR - Brazil
[3] Univ Estadual Campinas, Fac Odontol Piracicaba, Dept Diagnost Oral, BR-13414018 Piracicaba, SP - Brazil
[4] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[5] Univ Fed Parana, Setor Ciencias Biol, Dept Zool, Ctr Politecn, BR-81531990 Curitiba, Parana - Brazil
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of the Brazilian Chemical Society; v. 20, n. 4, p. 704+, 2009. |
| Citações Web of Science: | 11 |
| Resumo | |
The chemical investigation of the crude extract of an ascidian of the genus Didemnumled to the isolation of the modified diketopiperazine rodriguesines A (1) and (2) as a mixture of homologues, which could be identified by analysis of spectroscopic data including MS/MS experiments. The investigation of a second Didemnumsp. led to the isolation of N-acetyl-rodriguesine A (3) and N-acetyl-rodriguesine B (4). The absolute configuration of compounds 1and 2could be established by hydrolysis and Marfey's analysis and comparison with literature data reported for compound 3, previously obtained as a synthetic product. The mixture of 1and 2displayed moderate antibiotic activity against a clinical isolate of Streptococcus mutansand against S. mutansUA159 and Staphylococcus aureusATCC6538. (AU) | |
| Processo FAPESP: | 05/60175-2 - Descoberta e desenvolvimento de potenciais agentes quimioterápicos a partir de invertebrados marinhos e de microrganismos associados |
| Beneficiário: | Roberto Gomes de Souza Berlinck |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa BIOTA - Temático |