| Texto completo | |
| Autor(es): |
Araujo Guedes, Rubem Carlos
[1]
;
Cortes de Oliveira, Jose Antonio
[2]
;
Amancio-dos-Santos, Angela
[3]
;
Garcia-Cairasco, Norberto
[2]
Número total de Autores: 4
|
| Afiliação do(s) autor(es): | [1] Univ Fed Pernambuco, Physiol Lab, Dept Nutr, BR-50670901 Recife, PE - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Physiol, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Univ Fed Pernambuco, Dept Physiol & Pharmacol, BR-50670901 Recife, PE - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Epilepsy Research; v. 83, n. 2-3, p. 207-214, FEB 2009. |
| Citações Web of Science: | 22 |
| Resumo | |
Brain excitability diseases like epilepsy constitute one factor that influences brain electrophysiological features. Cortical spreading depression (CSD) is a phenomenon that can be altered by changes in brain excitability. CSD propagation was presently characterized in adult mate and female rats from a normal Wistar strain and from a genetically audiogenic seizure-prone strain, the Wistar audiogenic rat (WAR), both previously submitted (RAS(+)), or not (RAS(-)), to repetitive acoustic stimulation, to provoke audiogenic kindling in the WAR-strain. A gender-specific change in CSD-propagation was found. Compared to seizure-resistant animals, in the RAS- condition, mate and female WARs, respectively, presented CSD-propagation impairment and facilitation, characterized, respectively, by lower and higher propagation velocities (P<0.05). In contraposition, in the RAS(+) condition, mate and female WARs displayed, respectively, higher and tower CSD-propagation rates, as compared to the corresponding controls. In some Wistar and WAR females, we determined estrous cycle status on the day of the CSD-recording as being either estrous or diestrous; no cycle-phase-related differences in CSD-propagation velocities were detected. In contrast to other epilepsy models, such as Status Epilepticus induced by pilocarpine, despite the CSD-velocity reduction, in no case was CSD propagation blocked in WARs. The results suggest a gender-related, estrous cycle-phase-independent modification in the CSD-susceptibility of WAR rats, both in the RAS(+) and RAS(-) situation. (C) 2008 Elsevier B.V. All rights reserved. (AU) | |
| Processo FAPESP: | 05/56447-7 - Pesquisa através de imagens por ressonância magnética de alto campo destinadas a estudos em humanos |
| Beneficiário: | João Pereira Leite |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa CINAPCE - Temático |
| Processo FAPESP: | 03/00873-2 - Caracterização neuroetológica, video-EEgráfica e anatômica dos efeitos comportamentais e neurotóxicos da ingestão do suco de carambola (Averrhoa carambola) em ratos com insuficiência renal aguda |
| Beneficiário: | Norberto Garcia Cairasco |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |