Sexual differentiation of cortical spreading depression propagation after acute and kindled audiogenic seizures in the Wistar audiogenic rat (WAR)

Autor(es)

Araujo Guedes, Rubem Carlos ^[1] ; Cortes de Oliveira, Jose Antonio ^[2] ; Amancio-dos-Santos, Angela ^[3] ; Garcia-Cairasco, Norberto ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Pernambuco, Physiol Lab, Dept Nutr, BR-50670901 Recife, PE - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Physiol, BR-14049900 Ribeirao Preto, SP - Brazil

^[3] Univ Fed Pernambuco, Dept Physiol & Pharmacol, BR-50670901 Recife, PE - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Epilepsy Research; v. 83, n. 2-3, p. 207-214, FEB 2009.
• Citações Web of Science: 22

Resumo

Brain excitability diseases like epilepsy constitute one factor that influences brain electrophysiological features. Cortical spreading depression (CSD) is a phenomenon that can be altered by changes in brain excitability. CSD propagation was presently characterized in adult mate and female rats from a normal Wistar strain and from a genetically audiogenic seizure-prone strain, the Wistar audiogenic rat (WAR), both previously submitted (RAS(+)), or not (RAS(-)), to repetitive acoustic stimulation, to provoke audiogenic kindling in the WAR-strain. A gender-specific change in CSD-propagation was found. Compared to seizure-resistant animals, in the RAS- condition, mate and female WARs, respectively, presented CSD-propagation impairment and facilitation, characterized, respectively, by lower and higher propagation velocities (P<0.05). In contraposition, in the RAS(+) condition, mate and female WARs displayed, respectively, higher and tower CSD-propagation rates, as compared to the corresponding controls. In some Wistar and WAR females, we determined estrous cycle status on the day of the CSD-recording as being either estrous or diestrous; no cycle-phase-related differences in CSD-propagation velocities were detected. In contrast to other epilepsy models, such as Status Epilepticus induced by pilocarpine, despite the CSD-velocity reduction, in no case was CSD propagation blocked in WARs. The results suggest a gender-related, estrous cycle-phase-independent modification in the CSD-susceptibility of WAR rats, both in the RAS(+) and RAS(-) situation. (C) 2008 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 05/56447-7 - Pesquisa através de imagens por ressonância magnética de alto campo destinadas a estudos em humanos
• Beneficiário: João Pereira Leite
• Modalidade de apoio: Auxílio à Pesquisa - Programa CINAPCE - Temático
• Processo FAPESP: 03/00873-2 - Caracterização neuroetológica, video-EEgráfica e anatômica dos efeitos comportamentais e neurotóxicos da ingestão do suco de carambola (Averrhoa carambola) em ratos com insuficiência renal aguda
• Beneficiário: Norberto Garcia Cairasco
• Modalidade de apoio: Auxílio à Pesquisa - Regular