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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sexual differentiation of cortical spreading depression propagation after acute and kindled audiogenic seizures in the Wistar audiogenic rat (WAR)

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Author(s):
Araujo Guedes, Rubem Carlos [1] ; Cortes de Oliveira, Jose Antonio [2] ; Amancio-dos-Santos, Angela [3] ; Garcia-Cairasco, Norberto [2]
Total Authors: 4
Affiliation:
[1] Univ Fed Pernambuco, Physiol Lab, Dept Nutr, BR-50670901 Recife, PE - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Physiol, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Univ Fed Pernambuco, Dept Physiol & Pharmacol, BR-50670901 Recife, PE - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Epilepsy Research; v. 83, n. 2-3, p. 207-214, FEB 2009.
Web of Science Citations: 22
Abstract

Brain excitability diseases like epilepsy constitute one factor that influences brain electrophysiological features. Cortical spreading depression (CSD) is a phenomenon that can be altered by changes in brain excitability. CSD propagation was presently characterized in adult mate and female rats from a normal Wistar strain and from a genetically audiogenic seizure-prone strain, the Wistar audiogenic rat (WAR), both previously submitted (RAS(+)), or not (RAS(-)), to repetitive acoustic stimulation, to provoke audiogenic kindling in the WAR-strain. A gender-specific change in CSD-propagation was found. Compared to seizure-resistant animals, in the RAS- condition, mate and female WARs, respectively, presented CSD-propagation impairment and facilitation, characterized, respectively, by lower and higher propagation velocities (P<0.05). In contraposition, in the RAS(+) condition, mate and female WARs displayed, respectively, higher and tower CSD-propagation rates, as compared to the corresponding controls. In some Wistar and WAR females, we determined estrous cycle status on the day of the CSD-recording as being either estrous or diestrous; no cycle-phase-related differences in CSD-propagation velocities were detected. In contrast to other epilepsy models, such as Status Epilepticus induced by pilocarpine, despite the CSD-velocity reduction, in no case was CSD propagation blocked in WARs. The results suggest a gender-related, estrous cycle-phase-independent modification in the CSD-susceptibility of WAR rats, both in the RAS(+) and RAS(-) situation. (C) 2008 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 05/56447-7 - Research through images from high field magnetic resonance aimed at studies in humans
Grantee:João Pereira Leite
Support Opportunities: Inter-institutional Cooperation in Support of Brain Research (CINAPCE) - Thematic Grants