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Characterization of depressive behaviors and morphological aspects involved in early life stress and audiogenic kindling in war strain

Grant number: 14/17959-1
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2015
Effective date (End): February 18, 2019
Field of knowledge:Health Sciences - Medicine
Principal researcher:Norberto Garcia Cairasco
Grantee:Lívea Dornela Godoy
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated scholarship(s):17/11339-0 - Early life stress and neurodevelopment: Contributions of glucocorticoid plasticity to maturational timing., BE.EP.DR

Abstract

Epilepsy is a chronic neurological condition characterized by an enduring predisposition to generate epileptic seizures and by the neurobiological, cognitive, psychological and social consequences of this condition. Depression is a disorder that affects millions of people worldwide, causing a great impact on quality of life of patients. It is well known that depression is a very common psychiatric comorbidity in patients with epilepsy. Data suggest that epilepsy, particularly Temporal Lobe Epilepsy, Depression and other psychiatric disorders such as anxiety possible share pathogenic mechanisms. Accordingly, abnormalities were found in WAR rat that makes this strain an interesting model for the study of stress, epilepsy and neuropsychiatric comorbidities involved. The animals of this strain show higher levels of anxiety, reduction of serotonin in the dorsal raphe nucleus and in addition adrenal hyperplasia. Based on this, this study aims to assess whether the WAR strain presents depressive like behaviors and morphological features associated with the Early Life Stress (ELS) and audiogenic kindling. It will be used an ELS multimodal protocol (four different stressors) PN1 - PN21 in WAR and Wistar rats. Later, from PN70 - 80 it will be induced audiogenic kindling and depressive like behavior evaluated through forced swim test and sucrose consumption. At the end of the behavioral tests it will be performed radioimmunoassay test for quantification of corticosterone levels, immunohistochemical labeling for tryptophan hydroxylase enzyme, doublecortin (DCX) and GAD -67 enzyme. (AU)

News published in Agência FAPESP Newsletter about the scholarship:

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GODOY, LIVEA DORNELA; GARCIA-CAIRASCO, NORBERTO. Maternal behavior and the neonatal HPA axis in the Wistar Audiogenic Rat (WAR) strain: Early-life implications for a genetic animal model in epilepsy. Epilepsy & Behavior, v. 117, APR 2021. Web of Science Citations: 0.
GODOY, LIVEA DORNELA; ROSSIGNOLI, MATHEUS TEIXEIRA; DELFINO-PEREIRA, POLIANNA; GARCIA-CAIRASCO, NORBERTO; DE LIMA UMEOKA, EDUARDO HENRIQUE. A Comprehensive Overview on Stress Neurobiology: Basic Concepts and Clinical Implications. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, v. 12, JUL 3 2018. Web of Science Citations: 19.
GODOY, LIVEA DORNELA; UMEOKA, EDUARDO H. L.; RIBEIRO, DEIDIANE ELISA; SANTOS, VICTOR RODRIGUES; ANTUNES-RODRIGUES, JOSE; LOURENCO JOCA, SAMIA REGIANE; GARCIA-CAIRASCO, NORBERTO. Multimodal early-life stress induces biological changes associated to psychopathologies. Hormones and Behavior, v. 100, p. 69-80, APR 2018. Web of Science Citations: 3.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.