Occurrence of yeasts, pseudomonads and enteric bacteria in the oral cavity of patients undergoing head and neck radiotherapy

Autor(es)

Gaetti-Jardim Junior, Elerson ^[1] ; Nicolas Ciesielski, Francisco Isaak ; Nunes de Sousa, Fatima Regina ; Nwaokorie, Francisca ^[2] ; Schweitzer, Christiane Marie ^[3] ; Avila-Campos, Mario Julio ^[4]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, UNESP, Dept Patol & Propedeut Clin, FOA, Lab Microbiol & Imunol, Fac Odontol, BR-16015050 Aracatuba, SP - Brazil

^[2] Univ Lagos, Coll Med, Dept Med Microbiol & Parasitol, Lagos - Nigeria

^[3] Univ Estadual Paulista, Fac Engn, Dept Matemat, Ilha Solteira, SP - Brazil

^[4] Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Microbiology; v. 42, n. 3, p. 1046-1054, JUL-SEP 2011.
• Citações Web of Science: 5

Resumo

The aim of this study was to evaluate the occurrence of yeasts, pseudomonads and enteric bacteria in the oral cavity of patients undergoing radiotherapy (RT) for treatment of head and neck cancer. Fifty patients receiving RT were examined before, during and 30 days after RT. Saliva, mucosa, and biofilm samples were collected and microorganisms were detected by culture and polymerase chain reaction (PCR). The most prevalent yeasts in patients submitted to RT were Candida albicans, C. tropicalis, C. krusei, C. glabrata and C. parapsilosis. Citrobacter, Enterobacter, Enterococcus, Klebsiella, Proteus, and Pseudomonas were the most frequently cultivated bacteria. Before RT, targeted bacteria were cultivated from 22.2% of edentulous patients and 16.6% of dentate patients; 30 days after RT, these microorganisms were recovered from 77.8% edentulous and 46.8% dentate patients. By PCR, these microorganisms were detected from all edentulous patients, 78.1% of dentate patients. The presence of Gram-negative enteric roads and fungi was particularly frequent in patients presenting mucositis level III or IV. Modifications in the oral environment due to RT treatment seem to facilitate the colonization of oral cavity by members of family Enterobacteriaceae, genera Enterococcus and Candida. (AU)

• Processo FAPESP: 07/54851-0 - Avaliação da microbiota bucal de pacientes submetidos à radioterapia para tratamento de lesões malignas de cabeça e pescoço
• Beneficiário: Elerson Gaetti Jardim Júnior
• Modalidade de apoio: Auxílio à Pesquisa - Regular