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MODIFIED BACTERIAL STRAIN AND USE THEREOF 

Document type:Patente
Inventor(s): Angelo Berchieri Junior
Applicant: Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Universidade Estadual Paulista (UNESP)
Deposit date: December 2010, 22
INPI register:
PCT/BR2010/000431 - INPI Search
IPC: C12Q 1/68 C12N 15/66 A61K 39/112 C12R 1/42
Abstract

The present invention relates to a mutant of Salmonella gallinarum that is defective in the CobS and CbiA (SGCobSCbiA) genes, which are associated with the production of cobalamin by the bacterium in anaerobic conditions, for use as vaccines. The present invention also relates to the use of said mutant Salmonella gallinarum strain for inducing protection in birds against infection by the homologous natural strain and Salmonella enteritidis strain by means of a vaccine. (FR)La présente invention concerne un mutant de Salmonella gallinarum défectif dans les gènes CobS et CbiA (SGCobSCbiA), qui sont associés à la production de cobalamine par la bactérie dans des conditions anaérobies, en vue d'une utilisation comme vaccins. La présente invention concerne également l'utilisation de ladite souche mutante de Salmonella gallinarum pour induire chez des oiseaux une protection contre l'infection par la souche homologue naturelle et la souche de Salmonella enteritidis au moyen d'un vaccin.


FAPESP's process: 08/01386-1 - Immunization of poultry by an attenuated strain of Salmonella gallinarum
Grantee:Angelo Berchieri Junior
Principal Investigator:Angelo Berchieri Junior
Institution: Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Faculdade de Ciências Agrárias e Veterinárias (FCAV)
Support type: Research Grants - Support for Intellectual Property Rights and Licensing (PAPI/Nuplitec)