Oral epithelial stem cells: evaluation of response to injury and self-renew capacity

• Processo: 10/51462-6
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Vigência: 01 de dezembro de 2010 - 31 de agosto de 2011
• Área do conhecimento: Ciências da Saúde - Odontologia - Clínica Odontológica
• Convênio/Acordo: King's College London
• Pesquisador responsável: Andrea Mantesso Pobocik
• Beneficiário: Andrea Mantesso Pobocik
• Pesq. responsável no exterior: Paul T. Sharpe
• Instituição no exterior: King's College London, Inglaterra
• Instituição Sede: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brasil
• Vinculado ao auxílio: 08/11641-9 - Isolamento, caracterização e análise da resposta à injúria de células-tronco epiteliais da mucosa bucal humana, AP.R
• Assunto(s): Mucosa bucal Células-tronco
• Palavra(s)-Chave do Pesquisador: Oral Mucosa | Stem Cells | Tissue Engineering

Resumo

The oral mucosa has been increasingly used as a source of cells for tissue engineering and regenerative medicine as it has a rapid turnover that can be interpreted as strong self-renewal ability. So far, it is known that the epithelial stem cells are rare and located in specific niches, but their isolation remains a challenge. Currently in Sao Paulo we are attempting to identify, isolate and characterize a population of progenitors/stem cells from oral keratinocyte cultures based on cell surface markers. Further in London (England), we aim test these cells behavior by doing in vivo analysis using the mouse genetic model sat KCL. (AU)