Effects and neurobiological mechanisms of environmental manipulations on ethanol and nicotine induced behavioural effects: involvement of the stress circuitry

• Processo: 12/50207-8
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Data de Início da vigência: 01 de junho de 2012
• Data de Término da vigência: 31 de maio de 2014
• Área do conhecimento: Ciências Biológicas - Farmacologia - Neuropsicofarmacologia
• Acordo de Cooperação: University of Surrey
• Pesquisador responsável: Rosana Camarini
• Beneficiário: Rosana Camarini
• Pesquisador Responsável no exterior: Alexis Bailey
• Instituição Parceira no exterior: University of Surrey, Inglaterra
• Instituição Sede: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brasil
• Assunto(s): Tratamento farmacológico Síndrome de abstinência a substâncias Alcoolismo Nicotina
• Palavra(s)-Chave do Pesquisador: Alcohol | Crf | Environmental Enrichment | Nicotine | Oxytocin | Vasopressin

Resumo

Alcohol abuse is a chronic relapsing disorder with severe health and socioeconomic consequences. The biggest hurdle in treating recovering alcohol addicts and abstinent smokers is the maintenance of a long term drug free or abstinent state, as relapse is very common. Current pharmacotherapy is considered generally ineffective in prolonging abstinence and preventing relapse to alcohol and nicotine use, while environmental enrichement (EE) has been shown to cause positive impact on drug, craving. Camarini's group has demonstrated that environmental enrichment (EE) reversed and decreased ethanol-behavioral sensitization in mice and Bailey's group demonstrated that nicotine withdrawal symptoms are attenuated during, and following moderate intensity exercise in humans. The use of EE and exercise as a cessation method for alcohol and nicotine administration has a number of advantages over other cessation methods, e.g., not invasive, cost effective, involves no pharmacological interventions and has potential for use with groups who can not use more conventional cessation aids, e.g., pregnant women. The aim of this colaborative project is to identify possible mechanisms by which enviromental enrichement and exercise may influence nicotine and alcohol related behaviours, especially addictive related ones. (AU)

Publicações científicas

(4)

(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)

KEYWORTH, HELEN; GEORGIOU, POLYMNIA; ZANOS, PANOS; RUEDA, ANDRE VELOSO; CHEN, YING; KITCHEN, IAN; CAMARINI, ROSANA; CROPLEY, MARK; BAILEY, ALEXIS. Wheel running during chronic nicotine exposure is protective against mecamylamine-precipitated withdrawal and up-regulates hippocampal alpha 7 nACh receptors in mice. British Journal of Pharmacology, v. 175, n. 11, SI, p. 1928-1943, JUN 2018. (12/50207-8)

SANTOS-ROCHA, JAQUELINE BORGES; RAE, MARIANA; ARISTIMUNHO TEIXEIRA, ANA MARIA; TEIXEIRA, SIMONE APARECIDA; MUNHOZ, CAROLINA DEMARCHI; MUSCARA, MARCELO NICOLAS; MARCOURAKIS, TANIA; SZUMLINSKI, KAREN K.; CAMARINI, ROSANA. Involvement of neuronal nitric oxide synthase in cross-sensitization between chronic unpredictable stress and ethanol in adolescent and adult mice. ALCOHOL, v. 68, p. 71-79, MAY 2018. (15/02397-0, 12/50207-8)

KEYWORTH, HELEN; GEORGIOU, POLYMNIA; ZANOS, PANOS; RUEDA, ANDRE VELOSO; CHEN, YING; KITCHEN, IAN; CAMARINI, ROSANA; CROPLEY, MARK; BAILEY, ALEXIS. Wheel running during chronic nicotine exposure is protective against mecamylamine-precipitated withdrawal and up-regulates hippocampal alpha 7 nACh receptors in mice. British Journal of Pharmacology, v. 175, n. 11, p. 16-pg., 2018-06-01. (12/50207-8)

RAE, MARIANA; ZANOS, PANOS; GEORGIOU, POLYMNIA; CHIVERS, PRITI; BAILEY, ALEXIS; CAMARINI, ROSANA. Environmental enrichment enhances conditioned place preference to ethanol via an oxytocinergic-dependent mechanism in male mice. Neuropharmacology, v. 138, p. 267-274, AUG 2018. (12/09854-0, 12/50207-8, 15/02397-0)