Participation of opioids in respiratory rhythmogenesis

• Processo: 03/09723-3
• Modalidade de apoio: Bolsas no Exterior - Pesquisa
• Data de Início da vigência: 03 de janeiro de 2005
• Data de Término da vigência: 28 de fevereiro de 2005
• Área de conhecimento: Ciências Biológicas - Fisiologia - Fisiologia Comparada
• Pesquisador responsável: Luciane Helena Gargaglioni Batalhão
• Beneficiário: Luciane Helena Gargaglioni Batalhão
• Pesquisador Anfitrião: Richard J. A. Wilson
• Instituição Sede: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brasil
• Instituição Anfitriã: University of Calgary, Canadá
• Assunto(s): Respiração animal Anfíbios Bulbo (sistema nervoso) Analgésicos opioides
• Palavra(s)-Chave do Pesquisador: Anfibios | Bulbo | Opioide | Pre-Botzinger | Respiracao | Ritmogenese

Resumo

The medulla is recognized as playing a key role in generating the respiratory rhythm. In anurans amphibians, two coupled but spatially distinct areas within the medulla are necessary for generating buccal and lung ventilation. Recent studies in mammals using opioids suggest that the mammalian respiratory rhythm generator may also be composed of two populations of rhythmogenic neurons: opioid-sensitive neurons (I neurons) located within the PreBotzinger Complex (preBötzC), and opioid-insensitive neurons (pre-l neurons) located within and rostral to the preBötzC. In this proposal, I will determine whether the lung and buccal oscillators are functionally similar to the I and Prel oscillators of mammals. I will test the hypothesis that the amphibian oscillators, like the mammalian oscillators, differ in their sensitivity to opioids. (AU)