ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF

The present invention relates to acyl-hydrazone compounds, in particular 3,4,5-trimethoxyphenyl-hydrazide derivatives, oxadiazole analogs and other similar compounds thereof, and to their use in the treatment of diseases associated with cell proliferation Drug use in various diseases such as leukemia, including acute lymphoblastic leukemia (ALL), tumors and inflammation. An acyl-hydrazone having similar activity to the compound used as a standard in the experiment (colchicine) has been obtained. The greater selectivity of the compounds according to the invention is an important feature associated with less side effects compared to drugs currently used in clinical therapy. Synthetic acyl-hydrazones, more particularly compounds 02 and 07, exhibited significant anti-leukemic activity, suggesting that 02 and 07 may be useful in the treatment of leukemia, especially acute lymphoblastic leukemia (ALL), tumors and diseases such as inflammatory Drug prototypes or drug candidates for other proliferative diseases. In addition to selectivity studies in healthy human lymphocytes, the mechanism of action of the most active compounds was determined by testing using DNA microarrays followed by chip indication.