Anxiolytic effects of diphenyl diselenide on adult zebrafish in a novelty paradigm

Autor(es):Mostrar menos -

Ibrahim, Mohammad ^{[1, 2]} ; Mussulini, Ben Hur M. ^[1] ; Moro, Luana ^[1] ; de Assis, Adriano M. ^{[1, 3]} ; Rosemberg, Denis B. ^{[3, 4]} ; de Oliveira, Diogo L. ^[1] ; Rocha, Joao B. T. ^[4] ; Schwab, Ricardo S. ^[5] ; Schneider, Paulo Henrique ^[6] ; Souza, Diogo O. ^{[1, 3]} ; Rico, Eduardo P. ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Bioquim, Programa Posgrad Bioquim, BR-90035003 Porto Alegre, RS - Brazil

^[2] Univ Peshawar, Inst Chem Sci, Peshawar 25120, Khyber Pakhtunk - Pakistan

^[3] Inst Nacl Ciencia & Tecnol Excitotoxicidade & Neu, BR-90035003 Porto Alegre, RS - Brazil

^[4] Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Dept Bioquim & Biol Mol, Programa Pos Grad Bioquim Toxicol, BR-97105900 Santa Maria, RS - Brazil

^[5] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil

^[6] Univ Fed Rio Grande do Sul, Inst Quim, BR-91501970 Porto Alegre, RS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; v. 54, p. 187-194, OCT 3 2014.
• Citações Web of Science: 19

Resumo

Anxiety-related disorders are frequently observed in the population. Because the available pharmacotherapies for anxiety can cause side effects, new anxiolytic compounds have been screened using behavioral tasks. For example, diphenyl diselenide (PhSe)(2), a simple organoselenium compound with neuroprotective effects, has demonstrated anxiolytic effects in rodents. However, this compound has not yet been tested in a novelty-based paradigm in non-mammalian animal models. In this study, we assessed the potential anxiolytic effects of (PhSe)(2) on the behavior of adult zebrafish under novelty-induced stress. The animals were pretreated with 0.1, 0.25, 0.5, and 1 mu M (PhSe)(2) in the aquarium water for 30 min. The fish were then exposed to a novel tank, and their behavior was quantified during a 6-min trial. (PhSe)(2) treatment altered fish behavior in a concentration-dependent manner. At 0.01 and 0.25 mu M, (PhSe)(2) did not elicit effects on fish behavior. At 0.5 mu M, moderate behavioral side effects (e.g., lethargy and short episodic immobility) were noted. At the highest concentration tested (1 mu M), dramatic side effects were observed, such as burst behavior and longer periods of immobility. The results were confirmed by spatiotemporal analysis of each group. Occupancy plot data showed dispersed homebase formation in the 0.25 mu M (PhSe)(2)-treated group compared with the control group (treated with 0.04% DMSO). Furthermore, animals treated with 0.25 mu M (PhSe)(2) showed a reduction in latency to enter the top and spent more time in the upper area of the tank. These data suggest that (PhSe)(2) may induce an anxiolytic-like effect in situations of anxiety evoked by novelty. (C) 2014 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 13/06558-3 - Catálise metálica assimétrica: preparação de alcoóis quirais e seus derivados a partir de reagentes orgânicos de zinco poli-funcionalizados e aplicação de novos ligantes quirais suportados em nanopartículas magnéticas
• Beneficiário: Ricardo Samuel Schwab
• Linha de fomento: Auxílio à Pesquisa - Regular