Importance of the association of molecular and immunological diagnosis in immunocompetent patient with Histoplasma capsulatum and Cryptoccocus neoformans infection: a case report

Autor(es)

Dantas, Katia Cristina ^[1] ; de Freitas, Roseli Santos ^{[2, 3]} ; Pinto Garcia, Roberta Scholz ^{[2, 3]} ; da Silva, Marcos Vinicius ^[4] ; Mendes Muricy, Edna Cleide ^{[2, 3]} ; Kohara, Valdelene Sayuri ^[5] ; Vicentini, Adriana Pardini ^[5]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Trop Med, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Lab Med Mycol, LIM HCFMUSP 53, Sao Paulo - Brazil

^[4] Emilio Ribas Infect Dis Inst, Sao Paulo - Brazil

^[5] Adolfo Lutz Inst, Immunol Ctr, BR-01246902 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 20, AUG 26 2014.
• Citações Web of Science: 5

Resumo

This case reports an immunocompetent 29-year-old woman with suspected pneumonia, suggestive of fungal infection. Immunoblotting analysis reactivity againstHistoplasma capsulatum and Paracoccidioides brasiliensis were observed. Nested-PCR in blood employing species-specific primers was positive for H. capsulatum andCryptococcus neoformans. The evaluation of paucisymptomatic patients with positive results for H. capsulatum and C. neoformans could be relevant for the prevention as well as the possible evaluation of the reactivated quiescent foci. In conclusion, the associated methodology may have contributed to the monitoring endogenous reactivation of these diseases. (AU)

• Processo FAPESP: 09/50362-0 - Otimizacao do diagnostico laboratorial da histoplasmose em pacientes com aids
• Beneficiário: Paulo Ricardo Criado
• Modalidade de apoio: Auxílio à Pesquisa - Regular