PERFORMANCE OF PHALANGEAL QUANTITATIVE ULTRASOUND PARAMETERS IN THE EVALUATION OF REDUCED BONE MINERAL DENSITY ASSESSED BY DX IN PATIENTS WITH 21 HYDROXYLASE DEFICIENCY

Autor(es)

Goncalves, Ezequiel M. ^[1] ; Sewaybricker, Leticia E. ^{[1, 2, 3]} ; Baptista, Fatima ^[4] ; Silva, Analiza M. ^[4] ; Carvalho, Wellington R. G. ^{[1, 5]} ; Santos, Allan O. ^[6] ; de Mello, Maricilda P. ^[7] ; Lemos-Marini, Sofia H. V. ^[2] ; Guerra-Junior, Gil ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Fac Med Sci, Ctr Invest Pediat CIPED, Growth & Dev Lab, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Fac Med Sci, Dept Pediat, Pediat Endocrinol Unit, Campinas, SP - Brazil

^[3] PhD Student Program Child & Adolescent Hlth, Washington, DC - USA

^[4] Univ Lisbon, Fac Motricidade Humana, CIPER, Exercise & Hlth Lab, Cruz Quebrada - Portugal

^[5] Univ Fed Maranhao, Ctr Hlth & Biol Sci, Dept Phys Educ, Sao Luis, MA - USA

^[6] Univ Estadual Campinas, Clin Hosp, Nucl Med Div, Campinas, SP - Brazil

^[7] Univ Estadual Campinas, Ctr Mol Biol & Genet Engn, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ULTRASOUND IN MEDICINE AND BIOLOGY; v. 40, n. 7, p. 1414-1419, JUL 2014.
• Citações Web of Science: 1

Resumo

The purpose of this study was to verify the performance of quantitative ultrasound (QUS) parameters of proximal phalanges in the evaluation of reduced bone mineral density (BMD) in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21 OHD). Seventy patients with 21 OHD (41 females and 29 males), aged between 6-27 y were assessed. The QUS measurements, amplitude-dependent speed of sound (AD-SoS), bone transmission time (BTT), and ultrasound bone profile index (UBPI) were obtained using the BMD Sonic device (IGEA, Carpi, Italy) on the last four proximal phalanges in the non-dominant hand. BMD was determined by dual energy X-ray (DXA) across the total body and lumbar spine (LS). Total body and LS BMD were positively correlated to UBPI, BTT and AD-SoS (correlation coefficients ranged from 0.59-0.72, p < 0.001). In contrast, when comparing patients with normal and low (Z-score < -2) BMD, no differences were found in the QUS parameters. Furthermore, UBPI, BTT and AD-SoS measurements were not effective for diagnosing patients with reduced BMD by receiver operator characteristic curve parameters. Although the AD-SoS, BTT and UBPI showed significant correlations with the data obtained by DXA, they were not effective for diagnosing reduced bone mass in patients with 21 OHD. (E-mail: [e-mail]) (c) 2014 World Federation for Ultrasound in Medicine \& Biology. (AU)

• Processo FAPESP: 12/16778-8 - Avaliação cardiometabólica e do padrão de secreção de células beta pancreáticas em pacientes portadores de hiperplasia adrenal congênita
• Beneficiário: Gil Guerra Júnior
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/23460-1 - Risco cardiometabólico em pacientes com a forma clássica da Hiperplasia Adrenal Congênita por deficiência da enzima 21-hidroxilase.
• Beneficiário: Ezequiel Moreira Gonçalves
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado