Cord blood cytokine levels in focal early-onset neonatal infection after preterm premature rupture of membranes

Autor(es)

Kurokawa, Cilmery Suemi ^[1] ; Hashimoto, Miriam ^[1] ; Suppo de Souza Rugolo, Ligia Maria ^[1] ; Bentlin, Maria Regina ^[1] ; Golin, Marjorie de Assis ^[2] ; Peracoli, Jose Carlos ^[3] ; da Silva, Marcia Guimaraes ^[4] ; Corrente, Jose Eduardo ^[5] ; Wiegerinck Fekete, Saskia Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Dept Pediat, Sao Paulo - Brazil

^[2] Univ Estadual Paulista, Ctr Blood, Sao Paulo - Brazil

^[3] Univ Estadual Paulista, Dept Gynaecol & Obstet, Sao Paulo - Brazil

^[4] Univ Estadual Paulista, Dept Pathol, Botucatu Med Sch, Sao Paulo - Brazil

^[5] Univ Estadual Paulista, Biostat Dept, Biosci Inst Botucatu, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: TURKISH JOURNAL OF PEDIATRICS; v. 55, n. 6, p. 598-605, NOV-DEC 2013.
• Citações Web of Science: 2

Resumo

This study aimed to evaluate the levels of pro-and anti-inflammatory cytokines in umbilical cord blood of preterm neonates who developed focal early-onset infection (EOI) after preterm premature rupture of membranes (PPROM). This is a prospective study conducted on 46 preterm infants from mothers with PPROM. The cytokines were measure by flow cytometry. Newborns were classified into two groups as focal EOI (n=19) and non-infected (n=27). Interleukin (IL)-6 and IL-8 levels were higher, whereas IL-10 and IL-12 p70 levels were lower in the EOI when compared to the non-infected group. The best combination of cytokines was IL-6+IL-8, with a diagnostic accuracy of 0.97. Focal EOI after PPROM is associated with increased levels of IL-6 and IL-8 and diminished IL-10 and IL-12 in the cord blood of preterm infants. Combined assessment of IL-6 and IL-8 in cord blood may provide an additional tool for identifying preterm infants who develop EOI after PPROM. (AU)

• Processo FAPESP: 10/11507-0 - Cell symposia: inflammation and disease
• Beneficiário: Cilmery Suemi Kurokawa
• Modalidade de apoio: Auxílio à Pesquisa - Reunião - Exterior