| Afiliação do(s) autor(es): | [1] Univ Fed Sao Paulo, Dept Physiol, BR-04023060 Sao Paulo - Brazil
[2] Univ Fed Alagoas, Fac Nutr, BR-57072900 Maceio, AL - Brazil
Número total de Afiliações: 2
|
Undernutrition in early life has been reported to be closely associated with the development of non-communicable diseases in adulthood. Adequate treatment is important for reversing these effects. In the present study, we investigated the effects of undernutrition and anthropometric recovery on the weights and heights of children in relation to the concentrations of leptin, adiponectin and plasminogen activator inhibitor-1 (PAI-1). A total of 119 children (aged 616 years) from the slums of Sao Paulo were selected according to their nutritional status and divided into three groups as follows: control (healthy without intervention, n 38) with a height-for-age Z score (HAZ) and a BMI-for-age Z score (BAZ) > - 1.6; undernourished (HAZ and/or BAZ < - 1.6, n 54); recovered from undernutrition (after treatment in a rehabilitation centre; HAZ and BAZ > - 1.6, n 27). Blood samples were collected to determine insulin, glucose, leptin, adiponectin and PAI-1 concentrations. Leptin concentrations in the undernourished group were lower than those in the control and recovered groups (mean 0.92 (95 % CI 0.67, 1.25), 2.03 (95 % CI 1.46, 2.82) and 1.66 (95 % CI 1.15, 2.44) ng/ml, P=0.003), which had similar leptin concentrations. There were no differences in adiponectin and PAI-1 concentrations among the groups. A positive correlation between waist circumference and leptin concentrations was observed in all the girls and boys of the control group (control: r 0.729, P<0.01; undernourished: r 0.490, P<0.05; and recovered: r 0.829, P<0.01; r 0.673, P<0.05). Stronger correlations between leptin and insulin concentrations were observed in the recovered group. The results of the present study indicate that normal leptin concentrations are found when normal height and weight are achieved. (AU) |