Spatial distribution of theobromine - a low MW drug - in tissues via matrix-free NALDI-MS imaging

Autor(es)

Tata, Alessandra ^[1] ; Montemurro, Chiara ^[2] ; Porcari, Andreia M. ^[1] ; Silva, Kamila C. ^[2] ; Lopes de Faria, Jose B. ^[2] ; Eberlin, Marcos N. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Chem, ThoMSon Mass Spectrometry Lab, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Fac Med Sci, Renal Pathophysiol Lab, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: DRUG TESTING AND ANALYSIS; v. 6, n. 9, p. 949-952, SEP 2014.
• Citações Web of Science: 7

Resumo

The ability of nano-assisted laser desorption-ionization mass spectrometry imaging (NALDI-IMS) to provide selective chemical monitoring with appropriate spatial distribution of a low molecular drug in a biological tissue was investigated. NALDI-IMS is a matrix-free laser desorption ionization (LDI) protocol based on imprinting of tissue constituents on a nanostructured surface. Using the accumulation of theobromine in rat kidney as a model, NALDI-IMS was found to provide well-resolved images of the special distribution of this low molecular weight (MW) drug in tissue. Copyright (C) 2014 John Wiley \& Sons, Ltd. (AU)

• Processo FAPESP: 11/06191-7 - Fingerprinting por MALDI-TOF e ESI-MS para identificação de bactérias em meios de cultura de embriões e sêmen visando a excelência sanitária da produção in vitro de embriões bovinos
• Beneficiário: Alessandra Tata
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado