Spatial distribution of theobromine - a low MW drug - in tissues via matrix-free NALDI-MS imaging

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Author(s):	Tata, Alessandra ^[1] ; Montemurro, Chiara ^[2] ; Porcari, Andreia M. ^[1] ; Silva, Kamila C. ^[2] ; Lopes de Faria, Jose B. ^[2] ; Eberlin, Marcos N. ^[1] Total Authors: 6
Affiliation:	^[1] Univ Estadual Campinas, Inst Chem, ThoMSon Mass Spectrometry Lab, Campinas, SP - Brazil ^[2] Univ Estadual Campinas, Fac Med Sci, Renal Pathophysiol Lab, Campinas, SP - Brazil Total Affiliations: 2
Document type:	Journal article
Source:	DRUG TESTING AND ANALYSIS; v. 6, n. 9, p. 949-952, SEP 2014.
Web of Science Citations:	7
Abstract
The ability of nano-assisted laser desorption-ionization mass spectrometry imaging (NALDI-IMS) to provide selective chemical monitoring with appropriate spatial distribution of a low molecular drug in a biological tissue was investigated. NALDI-IMS is a matrix-free laser desorption ionization (LDI) protocol based on imprinting of tissue constituents on a nanostructured surface. Using the accumulation of theobromine in rat kidney as a model, NALDI-IMS was found to provide well-resolved images of the special distribution of this low molecular weight (MW) drug in tissue. Copyright (C) 2014 John Wiley \& Sons, Ltd. (AU)

FAPESP's process:	11/06191-7 - MALDI-TOF and ESI-MS fingerprinting for bacteria identification in culture media and semen as a tool for sanitary excelence in bovine embryo in vitro production
Grantee:	Alessandra Tata
Support Opportunities:	Scholarships in Brazil - Post-Doctoral