Serum and salivary macrophage migration inhibitory factor in patients with oral squamous cell carcinoma

Autor(es)

de Souza, Mariana Barbosa ^[1] ; Curioni, Otavio Alberto ^[2] ; Kanda, Jossi Ledo ^[3] ; De Carvalho, Marcos Brasilino ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo. Sch Med

^[2] Heliopolis Hosp. Mol Biol Lab

^[3] Padre Anchieta Teaching Hosp. ABC Med Sch

^[4] Heliopolis Hosp. Mol Biol Lab

• Tipo de documento: Artigo Científico
• Fonte: Oncology Letters; v. 8, n. 5, p. 2267-2275, NOV 2014.
• Citações Web of Science: 10

Resumo

The overexpression of macrophage migration inhibitory factor (MIF) has been identified in a variety of tumors and the investigation of its molecular mechanisms in tumor progression is a key topic of research. The present study aimed to investigate MIF as a potential marker for disease control or recurrence, and to assess the association between serum and salivary MIF and the clinicopathological characteristics of patients with oral squamous Cell carcinoma (OSCC). Serum and salivary samples were collected prior to and following the surgical treatment of 50 patients with OSCC. MIF concentrations were assessed by enzyme-linked immunosorbent assay and the adopted level of statistical significance was P<0.05. The results revealed that serum MIF concentrations were significantly reduced following tumor resection in OSCC patients. Furthermore, higher preoperative salivary MIF concentrations were observed in patients with larger tumors and in those who succumbed to the disease. In conclusion, high salivary and serological MIF concentrations were identified in patients with OSCC. Nevertheless, only serological MIF concentrations may be considered as a potential marker for the early detection of OSCC recurrence once the salivary levels, prior and following treatment, do not show any significant differences. (AU)

• Processo FAPESP: 11/03281-5 - Avaliação da expressão do fator inibitório da migração de macrófagos (MIF) como marcador prognóstico em pacientes com carcinoma epidermóide da cavidade bucal
• Beneficiário: MARIANA BARBOSA DE SOUZA RIZZO
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 10/20765-3 - Avaliação da expressão do fator inibitório da migração de macrófagos (MIF) como marcador prognóstico em pacientes com carcinoma epidermóide da cavidade bucal
• Beneficiário: Marcos Brasilino de Carvalho
• Modalidade de apoio: Auxílio à Pesquisa - Regular