Healthy individuals treated with clomipramine: an fMRI study of brain activity during autobiographical recall of emotions

Autor(es)

Cerqueira, C. T. ^{[1, 2]} ; Sato, J. R. ^{[3, 4]} ; de Almeida, J. R. C. ^[5] ; Amaro, Jr., E. ^[3] ; Leite, C. C. ^[3] ; Gorenstein, C. ^{[1, 2, 6, 7]} ; Gentil, V. ^{[1, 2]} ; Busatto, G. F. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Dept & Inst Psychiat, BR-05430010 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Hosp Clin, BR-05430010 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Dept & Inst Radiol, BR-05430010 Sao Paulo - Brazil

^[4] Fed Univ ABC, Dept Cognit Neurosci, Santo Andre - Brazil

^[5] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA - USA

^[6] Univ Sao Paulo, Sch Med, Lab Psychopharmacol LIM 23, BR-09500900 Sao Paulo - Brazil

^[7] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, BR-09500900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: TRANSLATIONAL PSYCHIATRY; v. 4, JUL 2014.
• Citações Web of Science: 3

Resumo

Various functional magnetic resonance imaging studies addressed the effects of antidepressant drugs on brain functioning in healthy subjects; however, none specifically investigated positive mood changes to antidepressant drug. Sixteen subjects with no personal or family history of psychiatric disorders were selected from an ongoing 4-week open trial of small doses of clomipramine. Follow-up interviews documented clear positive treatment effects in six subjects, with reduced irritability and tension in social interactions, improved decision making, higher self-confidence and brighter mood. These subjects were then included in a placebo-controlled confirmatory trial and were scanned immediately after 4 weeks of clomipramine use and again 4 weeks after the last dose of clomipramine. The functional magnetic resonance imaging (fMRI) scans were run during emotion-eliciting stimuli. Repeated-measures analysis of variance of brain activity patterns showed significant interactions between group and treatment status during induced irritability (P < 0.005 cluster-based) but not during happiness. Individuals displaying a positive subjective response do clomipramine had higher frontoparietal cortex activity during irritability than during happiness and neutral emotion, and higher temporo-parieto-occipital cortex activity during irritability than during happiness. We conclude that antidepressants not only induce positive mood responses but also act upon autobiographical recall of negative emotions. (AU)

• Processo FAPESP: 01/00189-9 - Estudo psicológico da regulação emocional a partir dos efeitos de antidepressivos
• Beneficiário: Valentim Gentil Filho
• Modalidade de apoio: Auxílio à Pesquisa - Temático