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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Healthy individuals treated with clomipramine: an fMRI study of brain activity during autobiographical recall of emotions

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Author(s):
Cerqueira, C. T. [1, 2] ; Sato, J. R. [3, 4] ; de Almeida, J. R. C. [5] ; Amaro, Jr., E. [3] ; Leite, C. C. [3] ; Gorenstein, C. [1, 2, 6, 7] ; Gentil, V. [1, 2] ; Busatto, G. F. [1, 2]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Sch Med, Dept & Inst Psychiat, BR-05430010 Sao Paulo - Brazil
[2] Univ Sao Paulo, Hosp Clin, BR-05430010 Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Dept & Inst Radiol, BR-05430010 Sao Paulo - Brazil
[4] Fed Univ ABC, Dept Cognit Neurosci, Santo Andre - Brazil
[5] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA - USA
[6] Univ Sao Paulo, Sch Med, Lab Psychopharmacol LIM 23, BR-09500900 Sao Paulo - Brazil
[7] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, BR-09500900 Sao Paulo - Brazil
Total Affiliations: 7
Document type: Journal article
Source: TRANSLATIONAL PSYCHIATRY; v. 4, JUL 2014.
Web of Science Citations: 3
Abstract

Various functional magnetic resonance imaging studies addressed the effects of antidepressant drugs on brain functioning in healthy subjects; however, none specifically investigated positive mood changes to antidepressant drug. Sixteen subjects with no personal or family history of psychiatric disorders were selected from an ongoing 4-week open trial of small doses of clomipramine. Follow-up interviews documented clear positive treatment effects in six subjects, with reduced irritability and tension in social interactions, improved decision making, higher self-confidence and brighter mood. These subjects were then included in a placebo-controlled confirmatory trial and were scanned immediately after 4 weeks of clomipramine use and again 4 weeks after the last dose of clomipramine. The functional magnetic resonance imaging (fMRI) scans were run during emotion-eliciting stimuli. Repeated-measures analysis of variance of brain activity patterns showed significant interactions between group and treatment status during induced irritability (P < 0.005 cluster-based) but not during happiness. Individuals displaying a positive subjective response do clomipramine had higher frontoparietal cortex activity during irritability than during happiness and neutral emotion, and higher temporo-parieto-occipital cortex activity during irritability than during happiness. We conclude that antidepressants not only induce positive mood responses but also act upon autobiographical recall of negative emotions. (AU)

FAPESP's process: 01/00189-9 - A psychobiological study of emotional regulation based on the effects of antidepressant drugs
Grantee:Valentim Gentil Filho
Support Opportunities: Research Projects - Thematic Grants