Mitochondrial calcium transport in trypanosomes

Autor(es)

Docampo, Roberto ^{[1, 2, 3]} ; Vercesi, Anibal E. ^[3] ; Huang, Guozhong ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Georgia, Ctr Trop & Emerging Global Dis, Athens, GA 30602 - USA

^[2] Univ Georgia, Dept Cellular Biol, Athens, GA 30602 - USA

^[3] Univ Estadual Campinas, Dept Patol Clin, BR-13083 Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Molecular and Biochemical Parasitology; v. 196, n. 2, p. 108-116, SEP 2014.
• Citações Web of Science: 15

Resumo

The biochemical peculiarities of trypanosomes were fundamental for the recent molecular identification of the long-sought channel involved in mitochondrial Ca2+ uptake, the mitochondrial Ca2+ uniporter or MCU. This discovery led to the finding of numerous regulators of the channel, which form a high molecular weight complex with MCU. Some of these regulators have been bioinformatically identified in trypanosomes, which are the first eukaryotic organisms described for which MCU is essential. In trypanosomes MCU is important for buffering cytosolic Ca2+ changes and for activation of the bioenergetics of the cells. Future work on this pathway in trypanosomes promises further insight into the biology of these fascinating eukaryotes, as well as the potential for novel target discovery. (C) 2014 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 11/50400-0 - Metabolismo energético, estado redox e funcionalidade mitocondrial na morte celular e em desordens cardiometabólicas e neurodegenerativas
• Beneficiário: Aníbal Eugênio Vercesi
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/50624-0 - Sinalização por íons de cálcio em tripanossomatídeos
• Beneficiário: Roberto Docampo
• Modalidade de apoio: Auxílio à Pesquisa - Programa SPEC