| Full text | |
| Author(s): |
Total Authors: 3
|
| Affiliation: | [1] Univ Georgia, Ctr Trop & Emerging Global Dis, Athens, GA 30602 - USA
[2] Univ Georgia, Dept Cellular Biol, Athens, GA 30602 - USA
[3] Univ Estadual Campinas, Dept Patol Clin, BR-13083 Campinas, SP - Brazil
Total Affiliations: 3
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| Document type: | Review article |
| Source: | Molecular and Biochemical Parasitology; v. 196, n. 2, p. 108-116, SEP 2014. |
| Web of Science Citations: | 15 |
| Abstract | |
The biochemical peculiarities of trypanosomes were fundamental for the recent molecular identification of the long-sought channel involved in mitochondrial Ca2+ uptake, the mitochondrial Ca2+ uniporter or MCU. This discovery led to the finding of numerous regulators of the channel, which form a high molecular weight complex with MCU. Some of these regulators have been bioinformatically identified in trypanosomes, which are the first eukaryotic organisms described for which MCU is essential. In trypanosomes MCU is important for buffering cytosolic Ca2+ changes and for activation of the bioenergetics of the cells. Future work on this pathway in trypanosomes promises further insight into the biology of these fascinating eukaryotes, as well as the potential for novel target discovery. (C) 2014 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 11/50400-0 - Mitochondrial energy metabolism, redox state and functionality in cell death and cardiometabolic and neurodegenerative disorders |
| Grantee: | Aníbal Eugênio Vercesi |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 13/50624-0 - Calcium signaling in trypanosomatids |
| Grantee: | Roberto Docampo |
| Support Opportunities: | Research Projects - SPEC Program |