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Mitochondrial function and dysfunction: implications for aging and associated diseases

Grant number: 17/17728-8
Support type:Research Projects - Thematic Grants
Duration: February 01, 2018 - January 31, 2023
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal researcher:Aníbal Eugênio Vercesi
Grantee:Aníbal Eugênio Vercesi
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Principal researchers:Helena Coutinho Franco de Oliveira ; Roger Frigério Castilho
Assoc. researchers:Andrei Carvalho Sposito ; Augusto Shinya Abe ; Marcelo Alves da Silva Mori ; Roberto Docampo
Associated grant(s):18/19976-1 - Chip-calorimetric investigations on the energy metabolism of Trypanosoma cruzi, AV.EXT
Associated scholarship(s):20/05202-4 - The role of mitochondrial NAD(P)+ transhydrogenase in monoaminergic neurotransmission and neurodegeneration in mice, BP.PD
19/20855-7 - The role of mitochondrial NAD(P)-Transhydrogenase in the development of Fatty Liver Disease and aging in mice, BP.PD
19/13862-7 - CETP influence on endothelial function and myocardial infarction: possible relation with mitochondrial function, BP.DD
+ associated scholarships 19/02340-0 - The impact of cholesteryl ester transfer protein (CETP) expression on adiposity in thermoneutral condition and obesogenic diet: focus on white adipose tissue, BP.MS
17/05487-6 - Mitochondrial function and molecular markers associated with aging in the long-lived red-footed tortoise Chelonoidis carbonaria, BP.PD
17/02903-9 - Role of CETP expression in the macrophage redox state: possible consequences to inflammation and atherosclerosis, BP.PD
17/03402-3 - Study of the association of mitochondrial and endoplasmic reticulum membranes in macrophages in the context of hypercholesterolemia: possible relevance for atherosclerosis, BP.PD
15/17555-0 - Impact of CETP expression on brown and beige adipose tissues and its contribution to the obesity control., BP.PD - associated scholarships


In the last 40 years, it has become evident that mitochondria are involved in many cell functions besides energy conversion, such as the control of cell death via calcium and oxygen and nitrogen reactive species signaling. Elevated levels of calcium in the mitochondrial matrix stimulate the generation of reactive oxygen which promote the opening of an unspecific pore in the inner mitochondrial membrane, the Permeability Transition Pore (PTP). Opening of PTP and mitochondrial redox state alterations are associated with cell senescence and death, as well as with the progression of degenerative diseases and with aging. In addition, there is compelling evidence that further studies on the control of PTP opening in aging may open avenues to a better understanding of factors determining longevity. Therefore, the major goal of this project is to advance the knowledge about the mechanisms by which mitochondria exert their regulatory roles in cell life and death and in aging. For this purpose, we plan to use several models (mice, rats, Caenorhabditis elegans, turtles and trypanosomes) to study mitochondrial functions involved in calcium homeostasis, redox (um)balance, longevity, aging and aging-related diseases. The specific objectives are grouped in four research lines: I) nicotinamide nucleotides transhydrogenase, energy metabolism and cell viability; II) mitochondria, dyslipidemias, Atherosclerosis and Obesity; III) mitochondria and aging; and IV) mitochondria and calcium homeostasis in trypanosomatides. Each model will be used to answer specific hypotheses in an integrated and multidisciplinary way with the participation of all principal investigators and collaborators. (AU)

Scientific publications (21)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RENTZ, THIAGO; WANSCHEL, AMARYLIS C. B. A.; DE CARVALHO MOI, LEONARDO; LORZA-GIL, ESTELA; DE SOUZA, JANE C.; DOS SANTOS, RENATA R.; OLIVEIRA, HELENA C. F. The Anti-atherogenic Role of Exercise Is Associated With the Attenuation of Bone Marrow-Derived Macrophage Activation and Migration in Hypercholesterolemic Mice. FRONTIERS IN PHYSIOLOGY, v. 11, NOV 23 2020. Web of Science Citations: 0.
FRANCISCO, ANNELISE; ENGEL, DAIANE F.; FIGUEIRA, TIAGO R.; ROGERIO, FABIO; DE BEM, ANDREZA F.; CASTILHO, ROGER F. Mitochondrial NAD(P)(+) Transhydrogenase is Unevenly Distributed in Different Brain Regions, and its Loss Causes Depressive-like Behavior and Motor Dysfunction in Mice. Neuroscience, v. 440, p. 210-229, AUG 1 2020. Web of Science Citations: 0.
ROGINSKI, ANA CRISTINA; WAJNER, ALESSANDRO; CECATTO, CRISTIANE; WAJNER, SIMONE MAGAGNIN; CASTILHO, ROGER FRIGERIO; WAJNER, MOACIR; AMARAL, ALEXANDRE UMPIERREZ. Disturbance of bioenergetics and calcium homeostasis provoked by metabolites accumulating in propionic acidemia in heart mitochondria of developing rats. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, v. 1866, n. 5 MAY 1 2020. Web of Science Citations: 0.
CECATTO, CRISTIANE; AMARAL, ALEXANDRE UMPIERREZ; ROGINSKI, ANA CRISTINA; CASTILHO, ROGER FRIGERIO; WAJNER, MOACIR. Impairment of mitochondrial bioenergetics and permeability transition induction caused by major long-chain fatty acids accumulating in VLCAD deficiency in skeletal muscle as potential pathomechanisms of myopathy. TOXICOLOGY IN VITRO, v. 62, FEB 2020. Web of Science Citations: 0.
DE-BRITO, NATALIA M.; DUNCAN-MORETTI, JULIA; DA-COSTA, HAYANDRA C.; SALDANHA-GAMA, ROBERTA; PAULA-NETO, HEITOR A.; DORIGHELLO, GABRIEL G.; SIMOES, RAFAEL L.; BARJA-FIDALGO, CHRISTINA. Aerobic glycolysis is a metabolic requirement to maintain the M2-like polarization of tumor-associated macrophages. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v. 1867, n. 2 FEB 2020. Web of Science Citations: 0.
OLIVEIRA, HELENA C. F.; VERCESI, ANIBAL E. Mitochondrial bioenergetics and redox dysfunctions in hypercholesterolemia and atherosclerosis. MOLECULAR ASPECTS OF MEDICINE, v. 71, FEB 2020. Web of Science Citations: 0.
CECATTO, CRISTIANE; AMARAL, ALEXANDRE UMPIERREZ; WAJNER, ALESSANDRO; WAJNER, SIMONE MAGAGNIN; CASTILHO, ROGER FRIGERIO; WAJNER, MOACIR. Disturbance of mitochondrial functions associated with permeability transition pore opening induced by cis-5-tetradecenoic and myristic acids in liver of adolescent rats. MITOCHONDRION, v. 50, p. 1-13, JAN 2020. Web of Science Citations: 0.
SALERNO, ALESSANDRO G.; RENTZ, THIAGO; DORIGHELLO, GABRIEL G.; MARQUES, ANA CAROLINA; LORZA-GIL, ESTELA; WANSCHEL, AMARYLIS C. B. A.; DE MORAES, AUDREY; VERCESI, ANIBAL E.; OLIVEIRA, HELENA C. F. Lack of mitochondrial NADP(H)-transhydrogenase expression in macrophages exacerbates atherosclerosis in hypercholesterolemic mice. Biochemical Journal, v. 476, n. 24, p. 3769-3789, DEC 2019. Web of Science Citations: 0.
LORZA-GIL, ESTELA; GARCIA-AREVALO, MARTA; FAVERO, BIANCA CRISTINE; GOMES-MARCONDES, MARIA CRISTINA C.; OLIVEIRA, HELENA C. F. Diabetogenic effect of pravastatin is associated with insulin resistance and myotoxicity in hypercholesterolemic mice. JOURNAL OF TRANSLATIONAL MEDICINE, v. 17, n. 1 AUG 27 2019. Web of Science Citations: 0.
LERCHNER, JOHANNES; SARTORI, MARINA R.; VOLPE, PEDRO O. L.; LANDER, NOELIA; MERTENS, FLORIAN; VERCESI, ANIBAL E. Direct determination of anaerobe contributions to the energy metabolism of Trypanosoma cruzi by chip calorimetry. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 411, n. 17, p. 3763-3768, JUL 2019. Web of Science Citations: 0.
VISACRI, MARILIA B.; QUINTANILHA, JULIA C. F.; DE SOUSA, VANESSA M.; AMARAL, LAIS S.; AMBROSIO, ROSIANE DE F. L.; CALONGA, LUCIANE; CURI, SILVIA F. B. B.; LEME, MAYRA F. DE T.; CHONE, CARLOS T.; ALTEMANI, JOAO M. C.; MAZZOLA, PRISCILA G.; MALAGUTI, CARINA; VERCESI, ANIBAL E.; LIMA, CARMEN S. P.; MORIEL, PATRICIA. Can acetylcysteine ameliorate cisplatin-induced toxicities and oxidative stress without decreasing antitumor efficacy? A randomized, double-blind, placebo-controlled trial involving patients with head and neck cancer. CANCER MEDICINE, v. 8, n. 5, p. 2020-2030, MAY 2019. Web of Science Citations: 0.
FRANCISCO, ANNELISE; RONCHI, JULIANA A.; NAVARRO, CLAUDIA D. C.; FIGUEIRA, TIAGO R.; CASTILHO, ROGER F. Nicotinamide nucleotide transhydrogenase is required for brain mitochondrial redox balance under hampered energy substrate metabolism and high-fat diet. Journal of Neurochemistry, v. 147, n. 5, p. 663-677, DEC 2018. Web of Science Citations: 0.
VERCESI, ANIBAL E.; CASTILHO, ROGER F.; KOWALTOWSKI, ALICIA J.; DE OLIVEIRA, HELENA C. F.; DE SOUZA-PINTO, NADJA C.; FIGUEIRA, TIAGO R.; BUSANELLO, ESTELA N. B. Mitochondrial calcium transport and the redox nature of the calcium-induced membrane permeability transition. Free Radical Biology and Medicine, v. 129, p. 1-24, DEC 2018. Web of Science Citations: 8.
RUAS, JULIANA S.; SIQUEIRA-SANTOS, EDILENE S.; RODRIGUES-SILVA, ERIKA; CASTILHO, ROGER F. High glycolytic activity of tumor cells leads to underestimation of electron transport system capacity when mitochondrial ATP synthase is inhibited. SCIENTIFIC REPORTS, v. 8, NOV 26 2018. Web of Science Citations: 0.
MARQUES, ANA C.; BUSANELLO, ESTELA N. B.; DE OLIVEIRA, DIOGO N.; CATHARINO, RODRIGO R.; OLIVEIRA, HELENA C. F.; VERCESI, ANIBAL E. Coenzyme Q10 or Creatine Counteract Pravastatin-Induced Liver Redox Changes in Hypercholesterolemic Mice. FRONTIERS IN PHARMACOLOGY, v. 9, JUN 27 2018. Web of Science Citations: 7.

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