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The role of mitochondrial NAD(P)+ transhydrogenase in monoaminergic neurotransmission and neurodegeneration in mice

Grant number: 20/05202-4
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): May 01, 2020
Effective date (End): April 30, 2022
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal researcher:Roger Frigério Castilho
Grantee:Annelise Francisco
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:17/17728-8 - Mitochondrial function and dysfunction: implications for aging and associated diseases, AP.TEM

Abstract

Previous studies have shown that NAD(P)+ transhydrogenase (NNT) is relevant to maintenance of mitochondrial redox balance in mouse brain, especially under physiologically challenging conditions, such as after treatment with a high-fat diet. In this sense, this project aims at study the role of NNT activity in the development of age-related changes in the central nervous system using a mouse model. Changes in mitochondrial bioenergetics, oxidative damage and morphological changes related to aging in the brain of mice with and without functional NNT will be characterized. Besides, changes in neurotransmission and putative behavioral phenotypes in mice devoid of functional NNT will be evaluated. Methodological approaches will include behavioral assays, assessment of the bioenergetic and redox balance in isolated mitochondria, assessment of oxidative damage markers, immunoenzymatic assays and immunohistochemical and immunofluorescence analyzes in brain. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FIGUEIRA, TIAGO R.; FRANCISCO, ANNELISE; RONCHI, JULIANA A.; DOS SANTOS, GUILHERME R. R. M.; DOS SANTOS, WILLIAM; TREBERG, JASON R.; CASTILHO, ROGER F. NADPH supply and the contribution of NAD(P)(+) transhydrogenase (NNT) to H2O2 balance in skeletal muscle mitochondria. Archives of Biochemistry and Biophysics, v. 707, AUG 15 2021. Web of Science Citations: 0.
FRANCISCO, ANNELISE; FIGUEIRA, TIAGO REZENDE; CASTILHO, ROGER FRIGERIO. Mitochondrial NAD(P)(+) Transhydrogenase: From Molecular Features to Physiology and Disease. Antioxidants & Redox Signaling, AUG 2021. Web of Science Citations: 0.
FRANCISCO, ANNELISE; ENGEL, DAIANE F.; FIGUEIRA, TIAGO R.; ROGERIO, FABIO; DE BEM, ANDREZA F.; CASTILHO, ROGER F. Mitochondrial NAD(P)(+) Transhydrogenase is Unevenly Distributed in Different Brain Regions, and its Loss Causes Depressive-like Behavior and Motor Dysfunction in Mice. Neuroscience, v. 440, p. 210-229, AUG 1 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.