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Mitochondrial function and molecular markers associated with aging in the long-lived red-footed tortoise Chelonoidis carbonaria

Grant number: 17/05487-6
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): October 01, 2017
Effective date (End): September 30, 2020
Field of knowledge:Biological Sciences - Biochemistry
Principal Investigator:Aníbal Eugênio Vercesi
Grantee:Marina Rincon Sartori
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:17/17728-8 - Mitochondrial function and dysfunction: implications for aging and associated diseases, AP.TEM


Brazil follows the worldwide trend of a marked increase in the number of elderly people in the population. Therefore, factors associated with aging are drawing attention, due to the relationship of aging with chronic diseases, elderly life quality, medical assistance costs and mortality risk. Many aging studies using model organisms focus on the mitochondria, multifunctional organelles that in addition to provide energy to the cell, have signaling functions involved with longevity and cell death processes. Mitochondria are associated with aging mainly through the generation of reactive oxygen species (ROS), mitochondrial DNA mutations and general mitochondrial dysfunctions. Moreover, the opening of the permeability transition pore (PTP) has been associated with aging and with several degenerative diseases. We propose to investigate the factors associated with longevity in the red-footed tortoise Chelonoidis carbonaria, which exhibits slow functional loss with age. For that, we will evaluate the mitochondrial bioenergetics and ultrastructure, ROS generation, oxidative damage and antioxidant capacity in specimens with different ages, using rats as an established mammalian reference model. We will also determine molecular markers involved with cellular senescence, proteostasis and mitochondrial dynamics. Our project aims to identify mechanisms that in the future could be applied in interventions for the promotion of healthy aging and to reduce age-related disease prevalence. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LERCHNER, JOHANNES; SARTORI, MARINA R.; VOLPE, PEDRO O. L.; LANDER, NOELIA; MERTENS, FLORIAN; VERCESI, ANIBAL E. Direct determination of anaerobe contributions to the energy metabolism of Trypanosoma cruzi by chip calorimetry. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 411, n. 17, p. 3763-3768, JUL 2019. Web of Science Citations: 0.

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