Exacerbation of Autoimmune Neuro-Inflammation in Mice Cured from Blood-Stage Plasmodium berghei Infection

Autor(es):Mostrar menos -

Thome, Rodolfo ^[1] ; Bombeiro, Andre Luis ^[1] ; Issayama, Luidy Kazuo ^[1] ; Raposo, Catarina ^[2] ; Pinto Lopes, Stefanie Costa ^[3] ; da Costa, Thiago Alves ^[1] ; Di Gangi, Rosaria ^[1] ; Ferreira, Isadora Tassinari ^[1] ; Figueiredo Longhini, Ana Leda ^[4] ; Rodrigues Oliveira, Alexandre Leite ^[1] ; da Cruz Hoefling, Maria Alice ^[2] ; Maranhao Costa, Fabio Trindade ^[3] ; Verinaud, Liana ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Struct & Funct Biol, Inst Biol, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Dept Histol & Embryol, Inst Biol, Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Dept Genet Evolut & Bioagents, Inst Biol, Campinas, SP - Brazil

^[4] Univ Estadual Campinas, Dept Hematol, Fac Ciencias Med, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 9, n. 10 OCT 17 2014.
• Citações Web of Science: 5

Resumo

The thymus plays an important role shaping the T cell repertoire in the periphery, partly, through the elimination of inflammatory auto-reactive cells. It has been shown that, during Plasmodium berghei infection, the thymus is rendered atrophic by the premature egress of CD4(+)CD8(+) double-positive (DP) T cells to the periphery. To investigate whether autoimmune diseases are affected after Plasmodium berghei NK65 infection, we immunized C57BL/6 mice, which was previously infected with P. berghei NK65 and treated with chloroquine (CQ), with MOG(35-55) peptide and the clinical course of Experimental Autoimmune Encephalomyelitis (EAE) was evaluated. Our results showed that NK65+CQ+EAE mice developed a more severe disease than control EAE mice. The same pattern of disease severity was observed in MOG(35-55)-immunized mice after adoptive transfer of P. berghei-elicited splenic DP-T cells. The higher frequency of IL-17(+)- and IFN-gamma+-producing DP lymphocytes in the Central Nervous System of these mice suggests that immature lymphocytes contribute to disease worsening. To our knowledge, this is the first study to integrate the possible relationship between malaria and multiple sclerosis through the contribution of the thymus. Notwithstanding, further studies must be conducted to assert the relevance of malaria-induced thymic atrophy in the susceptibility and clinical course of other inflammatory autoimmune diseases. (AU)

• Processo FAPESP: 11/17965-3 - Efeito da atrofia tímica induzida pela infecção com Plasmodium berghei no estabelecimento e curso da encefalomielite autoimune experimental (EAE)
• Beneficiário: Liana Maria Cardoso Verinaud
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/13191-3 - Efeito da atrofia tímica induzida pela infecção com Plasmodium berghei sobre a indução e desenvolvimento da EAE experimental
• Beneficiário: Rodolfo Thomé
• Modalidade de apoio: Bolsas no Brasil - Doutorado