Autor(es)

Serrano, Solange M. T. ^[1] ; Oliveira, Ana K. ^[1] ; Menezes, Milene C. ^[1] ; Zelanis, Andre ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Inst Butantan, Lab Especial Toxinol Aplicada, Ctr Toxins Immune Response & Cell Signaling CeTIC, BR-05503000 Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo ICT UNIFESP, Inst Ciencia & Tecnol, Sao Jose Dos Campos - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Toxin Reviews; v. 33, n. 4, p. 169-184, DEC 2014.
• Citações Web of Science: 8

Resumo

By catalyzing limited proteolysis or extensive degradation, proteolytic enzymes determine the fate of most proteins in an organism. In the evolutionary process of snake venoms, genes encoding proteinases were tailored to generate potent toxins to target key physiological proteins and thereby play a critical role in prey capture, immobilization and defense against predators. In Bothrops jararaca, metalloproteinases and serine proteinases are among the most abundant toxins both in newborn and adult venoms. In this review, we examine the proteinase-rich venom proteome of B. jararaca and how the proteinases act in a complex and heterogeneous fashion to exert their deleterious local and systemic effects. (AU)

• Processo FAPESP: 13/07467-1 - CeTICS - Centro de Toxinas, Imuno-Resposta e Sinalização Celular
• Beneficiário: Hugo Aguirre Armelin
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 10/17328-0 - Caracterização proteômica comparativa da agregação plaquetária induzida pela trombina e pela PA-BJ, uma serinoproteinase do veneno da Bothrops jararaca.
• Beneficiário: Ana Karina de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado