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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

General anesthesia type does not influence serum levels of neutrophil gelatinase-associated lipocalin during the perioperative period in video laparoscopic bariatric surgery

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Autor(es):
Fernandes, Adriano [1] ; Ettinger, Joao [2] ; Amaral, Fabiano [1] ; Ramalho, Maria Jose [1] ; Alves, Rodrigo [1] ; Pinheiro Modolo, Norma Sueli [3]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Sao Rafael Hosp, Dept Anesthesiol, Salvador, BA - Brazil
[2] Sao Rafael Hosp, Dept Surg, Salvador, BA - Brazil
[3] Univ Estadual Paulista, UNESP, Dept Botucatu, Sch Med, Botucatu, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Clinics; v. 69, n. 10, p. 655-659, 2014.
Citações Web of Science: 0
Resumo

OBJECTIVES: Video laparoscopic bariatric surgery is the preferred surgical technique for treating morbid obesity. However, pneumoperitoneum can pose risks to the kidneys by causing a decrease in renal blood flow. Furthermore, as in other surgical procedures, laparoscopic bariatric surgery triggers an acute inflammatory response. Neutrophil gelatinase-associated lipocalin is an early and accurate biomarker of renal injury, as well as of the inflammatory response. Anesthetic drugs could offer some protection for the kidneys and could attenuate the acute inflammatory response from surgical trauma. The objective of this study was to compare the effects of two types of anesthetics, propofol and sevoflurane, on the serum levels of neutrophil gelatinase-associated lipocalin during the perioperative period in laparoscopic bariatric surgery. METHODS: Sixty-four patients scheduled for laparoscopic bariatric surgery were randomized into two anesthesia groups and were administered either total intravenous anesthesia (propofol) or inhalation anesthesia (sevoflurane). In the perioperative period, blood samples were collected at three time points (before anesthesia, 6 hours after pneumoperitoneum and 24 hours after pneumoperitoneum) and urine output was measured for 24 hours. Acute kidney injuries were evaluated by examining both the clinical and laboratory parameters during the postoperative period. The differences between the groups were compared using non-parametric tests. ReBEC (http://www.ensaiosclinicos.gov.br/rg/recruiting/): RBR-8wt2fy RESULTS: None of the patients developed an acute kidney injury during the study and no significant differences were found between the serum neutrophil gelatinase-associated lipocalin levels of the groups during the perioperative period. CONCLUSION: The choice of anesthetic drug, either propofol or sevoflurane, did not affect the serum levels of neutrophil gelatinase-associated lipocalin during the perioperative period in laparoscopic bariatric surgery. (AU)

Processo FAPESP: 10/17300-9 - Eficácia da anestesia venosa total (TIVA) em bloquear a elevação perioperatória do NGAL em cirurgia bariátrica videolaparoscópica
Beneficiário:Norma Sueli Pinheiro Módolo
Linha de fomento: Auxílio à Pesquisa - Regular