Brazilian embauba (Cecropia pachystachya) extract reduces renal lesions in 5/6 nephrectomized rats

Autor(es)

Maquiaveli, Claudia do C. ^[1] ; da Silva, Edson R. ^[2] ; Francescato, Heloisa D. C. ^[1] ; Costa, Roberto S. ^[3] ; Silva, Cleonice G. A. ^[1] ; Casarini, Dulce E. ^[4] ; Ronchi, Fernanda A. ^[4] ; Coimbra, Terezila M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Physiol, BR-14049900 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Vet Med, BR-14049900 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Pathol, BR-14049900 Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Dept Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM; v. 15, n. 4, p. 430-439, DEC 2014.
• Citações Web of Science: 1

Resumo

Introduction:Cecropia pachystachya (CP) is a plant rich in polyphenols which inhibits the angiotensin-converting enzyme (ACE) in vitro. Angiotensin II (AII) has an important role in the renal lesion provoked by 5/6 nephrectomy (NE). This study evaluated the CP extract effect on renal lesions provoked by 5/6 NE. Materials and methods: Male Wistar rats submitted to 5/6 NE were treated or not treated with CP extract and followed for 90 days. Systemic blood pressure (SBP), albuminuria, renal functional and structural parameters, ACE activity, urinary levels of monocyte chemoattrant protein-1 (MCP-1) and transforming growth factor (TGF-) were evaluated. Results: Albuminuria and hypertension were less intense in the treated (NE+CP) group compared to the untreated (NE) group. CP extract treatment reduced the fall in glomerular filtration rate observed in NE rats. Glomerulosclerosis, tubulointerstitial lesions, increase of macrophages and AII positive cells in the renal cortex, as well as increases in renal ACE activity, urinary levels of MCP-1 and TGF- were attenuated in NE rats by CP treatment. Conclusions: The treatment with CP extract reduced the SBP and functional and structural renal changes in 5/6 NE rats. These effects were associated with decreased AII expression, ACE activity and inflammation in the renal cortex. (AU)

• Processo FAPESP: 11/50391-0 - Efeito do extrado bruto e frações de Cecropia pahystachya (embaúba) na evolução da lesão renal provocada pela nefrectomia a 5/6
• Beneficiário: Terezila Machado Coimbra
• Modalidade de apoio: Auxílio à Pesquisa - Regular