BMI gain and insulin resistance among school-aged children: a population-based longitudinal study in the Brazilian Amazon

Autor(es)

Lourenco, Barbara H. ^[1] ; Gimeno, Suely G. A. ^[2] ; Cardoso, Marly A. ^[3] ; Team, ACTION Study

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Publ Hlth Nutr Program, BR-01246904 Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Prevent Med, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BRITISH JOURNAL OF NUTRITION; v. 112, n. 11, p. 1905-1910, DEC 14 2014.
• Citações Web of Science: 3

Resumo

Investigation of the determinants of metabolic outcomes associated with non-communicable diseases is increasingly important in developing countries, but such parameters have not been explored extensively during childhood. The present study assessed the impact of weight gain, measured as BMI-for-age Z-scores, on glucose and insulin concentrations, homeostasis model assessment index of insulin resistance (HOMA-IR) values, and systolic and diastolic blood pressure during school years among Amazonian children. A population-based prospective study of 696 children aged >4 to <= 10 years with complete anthropometric information at baseline (51% females and 86% of mixed race) was carried out; 411 children had data on metabolic parameters after a median follow-up period of 2.0 years (range 1.7-2.6 years). During follow-up, there was a significant increase in the proportion of overweight children (BMI-for-age Z-score >1) from 10.1 to 15.8% (P = 0.003). In linear regression models adjusted for the child's sex, age, race/ethnicity, baseline household wealth, birth weight and pubertal development stage, for each unit of BMI-for-age Z-score variation during follow-up, an increase of 8.58 (95% CI 7.68, 9.60) pmol/l in fasting plasma insulin concentrations and 1.47 (95% CI 1.30, 1.66) in HOMA-IR values was observed. There was no significant impact of weight gain on glucose concentrations and systolic and diastolic blood pressure. In conclusion, we found evidence that an increase in BMI during a 2-year period affected insulin resistance during school years. Considering the significant increase in overweight in this age group, special attention should be paid to monitoring increases in BMI in children from the Brazilian Amazon. (AU)

• Processo FAPESP: 08/57796-3 - Crescimento infantil e composição corporal na idade escolar: estudo prospectivo de base populacional em Acrelândia, Estado do Acre, Amazônia Ocidental Brasileira
• Beneficiário: Bárbara Hatzlhoffer Lourenço
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 07/53042-1 - Saude e nutricao de criancas pre-escolares da amazonia ocidental brasileira: um estudo de coorte.
• Beneficiário: Marly Augusto Cardoso
• Modalidade de apoio: Auxílio à Pesquisa - Regular