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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Lycopene supplementation reduces TNF-alpha via RAGE in the kidney of obese rats

Texto completo
Autor(es):
Pierine, D. T. [1, 2] ; Navarro, M. E. L. [1] ; Minatel, I. O. [1, 2] ; Luvizotto, R. A. M. [2, 3] ; Nascimento, A. F. [2, 3] ; Ferreira, A. L. A. [3] ; Yeum, K-J [2, 4] ; Correa, C. R. [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] UNESP, Botucatu Med School, Dept Pathol, BR-18618970 Botucatu, SP - Brazil
[2] Tufts Univ, Jean Mayer Human Nutr Res Ctr, Boston, MA 02111 - USA
[3] UNESP, Botucatu Med School, Dept Internal Med, BR-18618970 Botucatu, SP - Brazil
[4] Konkuk Univ, Coll Biomed & Hlth Sci, Div Food Biosci, Seoul - South Korea
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: NUTRITION & DIABETES; v. 4, NOV 2014.
Citações Web of Science: 16
Resumo

BACKGROUND: The kidney is a target organ for injuries caused by advanced glycation end products (AGEs) in obesity. The receptor of AGEs (RAGE) is proinflammatory and appears to have a role in the pathogenesis of renal disease due to obesity. OBJECTIVE: The aim was to verify the effect of obesity on renal damage and the effect of lycopene on these complications DESIGN AND METHODS: Male Wistar rats were randomly assigned to receive a control diet (C, n = 7) or a high-fat diet plus sucrose (HD+S, n = 14) for 6 weeks. After this period, the HD+S animals were randomized into two groups: HD+S (n = 7) and HD+S supplemented with lycopene (HD+S+L, n = 7). The animals received maize oil (C and HD+S) or lycopene (HD+S+L) for a 6-week period. RESULTS: The HD+S and HD+S+L animals demonstrated insulin resistance (OGTT glucose after 150 min; C: 117.6 +/- 3.9 < HD+S: 138.1 +/- 5.1 = HD+S+L: 137.8 +/- 5.2 mg dl(-1); P = 0.01); however, no changes were seen in fasting glucose, plasma lipids, blood pressure or renal function. Renal concentrations of RAGE and TNF-alpha increased in the HD+S group and lycopene supplementation restored these to control group values (RAGE: C: 3.1 +/- 0.3 = DH+S+L: 3.1 +/- 0.3 < DH+S: 3.6 +/- 0.4 mu g g(-1); P = 0.014; TNF-alpha: C: 227.8 +/- 2.7 = DH+S+L: 227.4 +/- 2.2 < DH+S: 238.7 +/- 3.0 pg/ml; P = 0.014). CONCLUSIONS: Lycopene may be beneficial in the prevention and treatment of oxidative stress and inflammation in the kidney due to obesity. (AU)

Processo FAPESP: 11/14132-0 - Papel do TLR-4 na resposta inflamatória e resistência insulínica no tecido adiposo em uma condição crônica de sobrecarga nutricional
Beneficiário:Camila Renata Corrêa
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 10/06100-9 - Efeito da suplementação com licopeno na obesidade em modelo experimental com ratos Zucker
Beneficiário:Ana Lucia do Anjos Ferreira
Modalidade de apoio: Auxílio à Pesquisa - Regular