Cardiac Autonomic Modulation of Children with Down Syndrome

Autor(es):Mostrar menos -

de Carvalho, Tatiana Dias ^{[1, 2]} ; de Abreu, Luiz Carlos ^{[3, 1]} ; Mustacchi, Zan ^[4] ; Marques Vanderlei, Luiz Carlos ^[5] ; Godoy, Moacir Fernandes ^[6] ; Raimundo, Rodrigo Daminello ^[1] ; Ferreira Filho, Celso ^[7] ; da Silva, Talita Dias ^{[1, 2]} ; Guilhoto, Laura ^[8] ; Perico, Viviane ^[8] ; Finotti, Vivian Ribeiro ^[2] ; Ferreira, Celso ^[2]

Afiliação do(s) autor(es)

^[1] Fac Med ABC FMABC, Lab Escrita Cient, Santo Andre, SP - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Disciplina Cardiol, Dept Med, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Saude Publ, Dept Saude Maternoinfantil, Sao Paulo - Brazil

^[4] Hosp Infantil Darcy Vargas, Ambulatorio Genet, Sao Paulo - Brazil

^[5] Univ Estadual Paulista UNESP, Fac Ciencias & Tecnol, Dept Fisioterapia, Presidente Prudente, SP - Brazil

^[6] Fac Med Sao Jose de Rio Preto FAMERP, Nucleo Transdisciplinar Estudos Caos & Complexida, Sao Jose Do Rio Preto, SP - Brazil

^[7] Univ Fed Sao Paulo UNIFESP, Dept Med, Disciplina Clin Med, Sao Paulo - Brazil

^[8] APAE SAO PAULO, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PEDIATRIC CARDIOLOGY; v. 36, n. 2, p. 344-349, FEB 2015.
• Citações Web of Science: 4

Resumo

The aim of this study is to analyze the autonomic modulation in children with Down syndrome (DS). The study was conducted with a convenience sample of children with DS and without heart disease, from the Genetics Clinic of the Hospital Infantil Darcy Vargas and APAE So Paulo, So Paulo, SP, Brazil. The control group was matched for sex and age. The analysis of autonomic modulation was performed using the indices of heart rate variability (HRV). The children remained in the supine position with spontaneous breathing for 20 min. Heart rate was recorded beat-to-beat. HRV analysis was performed in time and frequency domain. For data analysis, we used Student's t test: unpaired and Mann-Whitney. It was considered statistically significant at p < 0.05. From 75 children with DS, 50 were excluded, a total of 25 children {[}16 boys, 8.6 (1.4) years] participated in this study, and the control group also consisted of 25 children {[}16 boys, 9.0 (1.2) years] without the syndrome. The BMI of the volunteers with DS was higher than the controls {[}19.1 (2.9) vs. 15.8 (1.2), p < 0.0001]. There were differences between groups in the indices in frequency domain: LFms(2) {[}1242.1 (788.25) vs. 786.44 (481.90), p = 0.040], LFun {[}69.104 (11.247) vs. 57.348 (11.683), p = 0.0004], HFun {[}30.896 (11.247) vs. 42.520 (11.634), p = 0.0004] and LF/HF {[}2.594 (1.104) vs. 1.579 (0.9982), p = 0.0004]. No differences were observed in time domain indices. The results indicate increased indices representing the sympathetic branch of the autonomic nervous system and those that indicate the overall modulation in children with DS. (AU)

• Processo FAPESP: 10/18005-0 - Caracterização da modulação autonômica e do perfil antropométrico de crianças com síndrome de down
• Beneficiário: Tatiana Dias de Carvalho
• Modalidade de apoio: Bolsas no Brasil - Doutorado