Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Prenatal zinc reduces stress response in adult rat offspring exposed to lipopolysaccharide during gestation

Texto completo
Autor(es):
Galvao, Marcella C. [1] ; Chaves-Kirsten, Gabriela P. [1] ; Queiroz-Hazarbassanov, Nicolle [1] ; Carvalho, Virginia M. [1] ; Bernardi, Maria M. [2] ; Kirsten, Thiago B. [1, 2]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Vet Med, Dept Pathol, BR-05508270 Sao Paulo - Brazil
[2] Univ Paulista, BR-04026002 Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Life Sciences; v. 120, p. 54-60, JAN 1 2015.
Citações Web of Science: 8
Resumo

Aims: Previous investigations by our group have shown that prenatal treatment with lipopolysaccharide (LPS; 100 mu g/kg, intraperitoneally) on gestation day (GD) 9.5 in rats, which mimics infections by Gram-negative bacteria, induces short-and long-term behavioral and neuroimmune changes in the offspring. Because LPS induces hypozincemia, dams were treated with zinc after LPS in an attempt to prevent or ameliorate the impairments induced by prenatal LPS exposure. LPS can also interfere with hypothalamic-pituitary-adrenal (HPA) axis development; thus, behavioral and neuroendocrine parameters linked to HPA axis were evaluated in adult offspring after a restraint stress session. Main methods: We prenatally exposed Wistar rats to LPS (100 mu g/kg, intraperitoneally, on GD 9.5). One hour later they received zinc (ZnSO4, 2 mg/kg, subcutaneously). Adult female offspring that were in metestrus/diestrus were submitted to a 2 h restraint stress session. Immediately after the stressor, 22 kHz ultrasonic vocalizations, open field behavior, serum corticosterone and brain-derived neurotrophic factor (BDNF) levels, and striatal and hypothalamic neurotransmitter and metabolite levels were assessed. Key findings: Offspring that received prenatal zinc after LPS presented longer periods in silence, increased locomotion, and reduced serum corticosterone and striatal norepinephrine turnover compared with rats treated with LPS and saline. Prenatal zinc reduced acute restraint stress response in adult rats prenatally exposed to LPS. Significance: Our findings suggest a potential beneficial effect of prenatal zinc, in which the stress response was reduced in offspring that were stricken with infectious/inflammatory processes during gestation. (C) 2014 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 12/07007-8 - Possível prevenção ou tratamento dos prejuízos induzidos pela exposição no início da gestação ao lipopolissacarídeo em um modelo experimental de autismo
Beneficiário:Thiago Berti Kirsten
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado