Postoperative analgesic effects of epidural administration of neostigmine alone or in combination with morphine in dogs undergoing orthopedic surgery of the pelvic limbs

Autor(es)

Marucio, Rodrigo L. ^[1] ; Monteiro, Eduardo R. ^[2] ; Moroz, Ludmila R. ^[1] ; Fantoni, Denise T. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Vet Med & Anim Sci, Dept Surg, BR-05508270 Sao Paulo - Brazil

^[2] Univ Vila Velha, Fac Vet Med, BR-29102770 Vila Velha, ES - Brazil

^[3] Univ Sao Paulo, Fac Med, Lab Med Invest LIM 08, BR-01246903 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AMERICAN JOURNAL OF VETERINARY RESEARCH; v. 75, n. 11, p. 956-963, NOV 2014.
• Citações Web of Science: 4

Resumo

Objective-To evaluate the postoperative analgesic effects of epidural administration of morphine and neostigmine, either alone or in combination, in dogs. Animals-30 dogs undergoing orthopedic surgery on a pelvic limb. Procedures-Anesthetic protocols were standardized. At the end of surgery, 10 dogs each received 1 of 3 epidural treatments: morphine (0.1 mg/kg), neostigmine (5 mu g/kg), or morphine plus neostigmine (0.1 mg/kg and 5 mu g/kg, respectively). Postoperative pain scores and the need for rescue analgesia were evaluated for 24 hours. Results-Pain scores were higher in the neostigmine group, compared with scores for the morphine-neostigmine group, at 2 and 24 hours after surgery and higher in the morphine group than in the morphine-neostigmine group at 2 and 4 hours. During 24 hours, rescue analgesia was provided for 4, 7, and 2 of 10 dogs each in the morphine, neostigmine, and morphine-neostigmine groups, respectively. The number of dogs given rescue analgesia was significantly different among groups at 2, 3, 4, and 6 hours after surgery. Dogs in the morphine and morphine-neostigmine groups had a lower probability of receiving rescue analgesia within 24 hours than did dogs in the neostigmine group. Conclusions and Clinical Relevance-When administered epidurally, morphine alone or in combination with neostigmine provided effective postoperative analgesia in most dogs after orthopedic surgery, whereas neostigmine alone did not. Findings for this study suggested a potential role for neostigmine as an adjuvant for epidural analgesia in dogs undergoing orthopedic surgeries on the pelvic limbs. (AU)

• Processo FAPESP: 07/57604-4 - Efeitos analgesicos da neostigmina e morfina, isoladas e associadas, pela via peridural em caes com fraturas osseas nos membros posteriores
• Beneficiário: Denise Tabacchi Fantoni
• Modalidade de apoio: Auxílio à Pesquisa - Regular