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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Postoperative analgesic effects of epidural administration of neostigmine alone or in combination with morphine in dogs undergoing orthopedic surgery of the pelvic limbs

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Author(s):
Marucio, Rodrigo L. [1] ; Monteiro, Eduardo R. [2] ; Moroz, Ludmila R. [1] ; Fantoni, Denise T. [3]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Vet Med & Anim Sci, Dept Surg, BR-05508270 Sao Paulo - Brazil
[2] Univ Vila Velha, Fac Vet Med, BR-29102770 Vila Velha, ES - Brazil
[3] Univ Sao Paulo, Fac Med, Lab Med Invest LIM 08, BR-01246903 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: AMERICAN JOURNAL OF VETERINARY RESEARCH; v. 75, n. 11, p. 956-963, NOV 2014.
Web of Science Citations: 4
Abstract

Objective-To evaluate the postoperative analgesic effects of epidural administration of morphine and neostigmine, either alone or in combination, in dogs. Animals-30 dogs undergoing orthopedic surgery on a pelvic limb. Procedures-Anesthetic protocols were standardized. At the end of surgery, 10 dogs each received 1 of 3 epidural treatments: morphine (0.1 mg/kg), neostigmine (5 mu g/kg), or morphine plus neostigmine (0.1 mg/kg and 5 mu g/kg, respectively). Postoperative pain scores and the need for rescue analgesia were evaluated for 24 hours. Results-Pain scores were higher in the neostigmine group, compared with scores for the morphine-neostigmine group, at 2 and 24 hours after surgery and higher in the morphine group than in the morphine-neostigmine group at 2 and 4 hours. During 24 hours, rescue analgesia was provided for 4, 7, and 2 of 10 dogs each in the morphine, neostigmine, and morphine-neostigmine groups, respectively. The number of dogs given rescue analgesia was significantly different among groups at 2, 3, 4, and 6 hours after surgery. Dogs in the morphine and morphine-neostigmine groups had a lower probability of receiving rescue analgesia within 24 hours than did dogs in the neostigmine group. Conclusions and Clinical Relevance-When administered epidurally, morphine alone or in combination with neostigmine provided effective postoperative analgesia in most dogs after orthopedic surgery, whereas neostigmine alone did not. Findings for this study suggested a potential role for neostigmine as an adjuvant for epidural analgesia in dogs undergoing orthopedic surgeries on the pelvic limbs. (AU)