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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Zinc Prevents Sickness Behavior Induced by Lipopolysaccharides after a Stress Challenge in Rats

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Autor(es):
Kirsten, Thiago B. [1, 2] ; Galvao, Marcella C. [1] ; Reis-Silva, Thiago M. [1] ; Queiroz-Hazarbassanov, Nicolle [1] ; Bernardi, Maria M. [2]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Vet Med, Dept Pathol, Sao Paulo - Brazil
[2] Univ Estadual Paulista, Environm & Expt Pathol, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: PLoS One; v. 10, n. 3 MAR 16 2015.
Citações Web of Science: 9
Resumo

Sickness behavior is considered part of the specific beneficial adaptive behavioral and neuroimmune changes that occur in individuals in response to infectious/inflammatory processes. However, in dangerous and stressful situations, sickness behavior should be momentarily abrogated to prioritize survival behaviors, such as fight or flight. Taking this assumption into account, we experimentally induced sickness behavior in rats using lipopolysaccharides (LPS), an endotoxin that mimics infection by gram-negative bacteria, and then exposed these rats to a restraint stress challenge. Zinc has been shown to play a regulatory role in the immune and nervous systems. Therefore, the objective of this study was to examine the effects of zinc treatment on the sickness response of stress-challenged rats. We evaluated 22-kHz ultrasonic vocalizations, open-field behavior, tumor necrosis factor a (TNF-alpha), corticosterone, and brain-derived neurotrophic factor (BDNF) plasma levels. LPS administration induced sickness behavior in rats compared to controls, i.e., decreases in the distance traveled, average velocity, rearing frequency, self-grooming, and number of vocalizations, as well as an increase in the plasma levels of TNF-alpha, compared with controls after a stressor challenge. LPS also decreased BDNF expression but did not influence anxiety parameters. Zinc treatment was able to prevent sickness behavior in LPS-exposed rats after the stress challenge, restoring exploratory/motor behaviors, communication, and TNF-alpha levels similar to those of the control group. Thus, zinc treatment appears to be beneficial for sick animals when they are facing risky/stressful situations. (AU)

Processo FAPESP: 09/51886-3 - Neuroimunomodulação: fármacos, estresse e citocinas nas relações entre os sistemas nervoso, endócrino e imune
Beneficiário:João Palermo Neto
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 12/07007-8 - Possível prevenção ou tratamento dos prejuízos induzidos pela exposição no início da gestação ao lipopolissacarídeo em um modelo experimental de autismo
Beneficiário:Thiago Berti Kirsten
Linha de fomento: Bolsas no Brasil - Pós-Doutorado