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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

A flexible lab-on-a-chip for the synthesis and magnetic separation of magnetite decorated with gold nanoparticles

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Autor(es):
Cabrera, Flavio C. [1] ; Melo, Antonio F. A. A. [2] ; de Souza, Joao C. P. [2] ; Job, Aldo E. [1] ; Crespilho, Frank N. [2]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] UNESP, FCT, Dept Fis Quim & Biol, Presidente Prudente, SP - Brazil
[2] Univ Sao Paulo, Inst Quim, Sao Carlos, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: LAB ON A CHIP; v. 15, n. 8, p. 1835-1841, 2015.
Citações Web of Science: 9
Resumo

Magnetite decorated with gold nanoparticles (Fe3O4-AuNPs) is a ferrimagnetic material with unprecedented applications in immunosensors, as a contrast agent for imaging diagnosis, and for the photothermal ablation of tumor cells. Here, we show the preparation of controlled amounts of Fe3O4-AuNPs without organic solvents, surfactants, or heat treatment. For this, we have developed a customized natural-rubber-based microfluidic device (NRMD) as a flexible lab-on-a-chip for the decoration of Fe3O4 with AuNPs. With a novel NRMD configuration, monodisperse Fe3O4-NPs (phi = 10 nm) decorated with AuNPs (phi = 4 nm) were readily obtained. The AuNPs were homogenous in terms of their size and their distribution on the Fe3O4-NP surfaces. Furthermore, the lab-on-a-chip was projected with an internal system for magnetic separation, an innovation in terms of aqueous/carrier phase separation. Finally, the nanomaterials produced with this NRMD are free of organic solvents and surfactants, allowing them to be used directly for medical applications. (AU)

Processo FAPESP: 11/23362-0 - Dispositivo microfluídico de borracha natural (lab-on-a-chip)
Beneficiário:Flávio Camargo Cabrera
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 13/14262-7 - Filmes nanoestruturados de materiais de interesse biológico
Beneficiário:Osvaldo Novais de Oliveira Junior
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 13/04663-4 - Bioeletrodos enzimáticos aplicados em biocélulas a combustível: simulação e experimental
Beneficiário:Frank Nelson Crespilho
Linha de fomento: Auxílio à Pesquisa - Regular