| Texto completo | |
| Autor(es): |
Cabrera, Flavio C.
[1]
;
Melo, Antonio F. A. A.
[2]
;
de Souza, Joao C. P.
[2]
;
Job, Aldo E.
[1]
;
Crespilho, Frank N.
[2]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] UNESP, FCT, Dept Fis Quim & Biol, Presidente Prudente, SP - Brazil
[2] Univ Sao Paulo, Inst Quim, Sao Carlos, SP - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | LAB ON A CHIP; v. 15, n. 8, p. 1835-1841, 2015. |
| Citações Web of Science: | 8 |
| Resumo | |
Magnetite decorated with gold nanoparticles (Fe3O4-AuNPs) is a ferrimagnetic material with unprecedented applications in immunosensors, as a contrast agent for imaging diagnosis, and for the photothermal ablation of tumor cells. Here, we show the preparation of controlled amounts of Fe3O4-AuNPs without organic solvents, surfactants, or heat treatment. For this, we have developed a customized natural-rubber-based microfluidic device (NRMD) as a flexible lab-on-a-chip for the decoration of Fe3O4 with AuNPs. With a novel NRMD configuration, monodisperse Fe3O4-NPs (phi = 10 nm) decorated with AuNPs (phi = 4 nm) were readily obtained. The AuNPs were homogenous in terms of their size and their distribution on the Fe3O4-NP surfaces. Furthermore, the lab-on-a-chip was projected with an internal system for magnetic separation, an innovation in terms of aqueous/carrier phase separation. Finally, the nanomaterials produced with this NRMD are free of organic solvents and surfactants, allowing them to be used directly for medical applications. (AU) | |
| Processo FAPESP: | 11/23362-0 - Dispositivo microfluídico de borracha natural (lab-on-a-chip) |
| Beneficiário: | Flávio Camargo Cabrera |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 13/04663-4 - Bioeletrodos enzimáticos aplicados em biocélulas a combustível: simulação e experimental |
| Beneficiário: | Frank Nelson Crespilho |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 13/14262-7 - Filmes nanoestruturados de materiais de interesse biológico |
| Beneficiário: | Osvaldo Novais de Oliveira Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |