| Texto completo | |
| Autor(es): |
Castro, E. F. S.
[1]
;
Mostarda, C. T.
[2]
;
Rodrigues, B.
[3]
;
Moraes-Silva, I. C.
[1]
;
Feriani, D. J.
[3]
;
De Angelis, K.
[4]
;
Irigoyen, M. C.
[1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Fac Med, Inst Coracao, Unidade Hipertensao, Sao Paulo, SP - Brazil
[2] Univ Fed Maranhao, Sao Luis, MA - Brazil
[3] Univ Sao Judas Tadeu, Lab Movimento Humano, Sao Paulo, SP - Brazil
[4] Univ Nove Julho, Lab Fisiol Translac, Sao Paulo, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Brazilian Journal of Medical and Biological Research; v. 48, n. 4, p. 332-338, APR 2015. |
| Citações Web of Science: | 1 |
| Resumo | |
The present study aimed to study the effects of exercise training (ET) performed by rats on a 10-week high-fructose diet on metabolic, hemodynamic, and autonomic changes, as well as intraocular pressure (IOP). Male Wistar rats receiving fructose overload in drinking water (100 g/L) were concomitantly trained on a treadmill for 10 weeks (FT group) or kept sedentary (F group), and a control group (C) was kept in normal laboratory conditions. The metabolic evaluation comprised the Lee index, glycemia, and insulin tolerance test (KITT). Arterial pressure (AP) was measured directly, and systolic AP variability was performed to determine peripheral autonomic modulation. ET attenuated impaired metabolic parameters, AP, IOP, and ocular perfusion pressure (OPP) induced by fructose overload (FT vs F). The increase in peripheral sympathetic modulation in F rats, demonstrated by systolic AP variance and low frequency (LF) band (F: 37±2, 6.6±0.3 vs C: 26±3, 3.6±0.5 mmHg2), was prevented by ET (FT: 29±3, 3.4±0.7 mmHg2). Positive correlations were found between the LF band and right IOP (r=0.57, P=0.01) and left IOP (r=0.64, P=0.003). Negative correlations were noted between KITT values and right IOP (r=-0.55, P=0.01) and left IOP (r=-0.62, P=0.005). ET in rats effectively prevented metabolic abnormalities and AP and IOP increases promoted by a high-fructose diet. In addition, ocular benefits triggered by exercise training were associated with peripheral autonomic improvement. (AU) | |
| Processo FAPESP: | 12/20141-5 - Efeitos do treinamento físico aeróbio, resistido ou combinado em modelos experimentais de disfunções cardiometabólicas associadas à privação dos hormônios ovarianos |
| Beneficiário: | Kátia de Angelis Lobo D Avila |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 07/58942-0 - Da bancada à clínica: desenvolvimento de biomarcadores como preditores da resposta à terapêutica e lesão de órgãos-alvo na hipertensão arterial sistemática |
| Beneficiário: | Eduardo Moacyr Krieger |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |