Antioxidants and biomarkers of oxidative damage in the saliva of patients with Down's syndrome

Autor(es)

de Sousa, Michelle Cardoso ^[1] ; Vieira, Rafael Brizola ^[1] ; dos Santos, Danielle Sa ^[1] ; Talge Carvalho, Claudio Antonio ^[2] ; Afonso Camargo, Samira Esteves ^[1] ; Gasparoto Mancini, Maria Nadir ^[1] ; de Oliveira, Luciane Dias ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, UNESP, Sch Dent Sao Jose dos Campos, Dept Biosci & Oral Diag, BR-12245000 Sao Jose Dos Campos, SP - Brazil

^[2] Univ Estadual Paulista, UNESP, Sch Dent Sao Jose dos Campos, Dept Restorat Dent, BR-12245000 Sao Jose Dos Campos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF ORAL BIOLOGY; v. 60, n. 4, p. 600-605, APR 2015.
• Citações Web of Science: 11

Resumo

Background: The aim of this study was to investigate enzymatic and non-enzymatic antioxidant systems and levels of biomarker levels of oxidative damage in the saliva of patients with Down's syndrome (DS). Methods: Saliva samples were collected from 30 patients with DS and control group (age: 1424 years). Subsequently, the concentrations of superoxide dismutase, concentration of malondialdehyde, carbonylated proteins, uric acid, vitamin C and total protein, peroxidase activity and total antioxidant capacity were analyzed. Results: Patients with DS presented significantly higher concentrations of superoxide dismutase, higher levels of malondialdehyde and salivary total protein content than controls (p < 0.05). Conversely, no difference in carbonylated proteins or antioxidants (uric acid, vitamin C, peroxidase, and total antioxidant capacity) was observed between DS patients and controls (p > 0.05). Conclusion: Patients with DS are more vulnerable to oxidative stress in saliva as indicated by the significant increase in malondialdehyde and superoxide dismutase concentrations found in this study. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 09/51228-6 - Avaliação de antioxidantes e biomarcadores da injúria oxidativa na saliva de pacientes portadores de Síndrome de Down
• Beneficiário: Luciane Dias de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular