Garcinielliptone FC: Antiparasitic activity without cytotoxicity to mammalian cells

Autor(es)

Silva, Ana P. ^[1] ; Silva, Marcos P. ^[2] ; Oliveira, Cristiano G. ^[2] ; Monteiro, Daniela C. ^[2] ; Pinto, Pedro L. ^[3] ; Mendonca, Ronald Z. ^[4] ; Costa Junior, Joaquim S. ^[5] ; Freitas, Rivelilson M. ^[1] ; de Moraes, Josue ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Piaui, Programa Posgrad Biotecnol, Rede Nordeste Biotecnol, Teresina, PI - Brazil

^[2] NPDN, BR-07112090 Guarulhos, SP - Brazil

^[3] Adolfo Lutz Inst, Nucleo Enteroparasitas, Sao Paulo, SP - Brazil

^[4] Inst Butantan, Lab Parasitol, Sao Paulo, SP - Brazil

^[5] Inst Fed Piaui, Lab Prod Nat, Teresina, PI - Brazil

• Tipo de documento: Artigo Científico
• Fonte: TOXICOLOGY IN VITRO; v. 29, n. 4, p. 681-687, JUN 2015.
• Citações Web of Science: 15

Resumo

Garcinielliptone FC (GFC) is a natural prenylated benzophenone found in the seeds of Platonia insignis Mart. (Clusiaceae), a native Brazilian plant. It has been chemically characterized and it is known that GFC has several biological activities such as antioxidant and vasorelaxant properties. In this study, we report the in vitro effect of GFC against the blood fluke Schistosoma mansoni, the parasite responsible for schistosomiasis mansoni. The anti-S. mansoni activity and cytotoxicity toward mammalian cells were determined for the compound. GFC >= 6.25 mu M showed antischistosomal activity and confocal laser scanning microscopy analysis demonstrated several morphological alterations on the tegument of worms, and a correlation between viability and tegumental damage was observed. In addition, at sub-lethal concentrations of GFC (<= 3.125 mu M), the number of S. mansoni eggs was reduced. More importantly, GFC exhibited no activity toward mammalian cells and, therefore, there is an appreciable selectivity of this compound against the helminths. In conclusion, these findings indicate the potential of GFC as an antiparasitic agent. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 00/11624-5 - Embriologia de Gastropoda: análise em microscopia de varredura laser confocal
• Beneficiário: Toshie Kawano
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários