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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Non-synonymous mutations mapped to chromosome X associated with andrological and growth traits in beef cattle

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Autor(es):
Ferreira de Camargo, Gregorio Miguel [1, 2, 3] ; Porto-Neto, Laercio R. [1] ; Kelly, Matthew J. [3] ; Bunch, Rowan J. [1] ; McWilliam, Sean M. [1] ; Tonhati, Humberto [2] ; Lehnert, Sigrid A. [1] ; Fortes, Marina R. S. [3] ; Moore, Stephen S. [4]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] CSIRO, Agr Flagship, St Lucia, Qld 4067 - Australia
[2] Univ Estadual Paulista Unesp, Dept Zootecnia, BR-14884900 Jaboticabal, SP - Brazil
[3] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072 - Australia
[4] Univ Queensland, Ctr Anim Sci, Queensland Alliance Agr & Food Innovat, Brisbane, Qld 4067 - Australia
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: BMC Genomics; v. 16, MAY 15 2015.
Citações Web of Science: 13
Resumo

Background: Previous genome-wide association analyses identified QTL regions in the X chromosome for percentage of normal sperm and scrotal circumference in Brahman and Tropical Composite cattle. These traits are important to be studied because they are indicators of male fertility and are correlated with female sexual precocity and reproductive longevity. The aim was to investigate candidate genes in these regions and to identify putative causative mutations that influence these traits. In addition, we tested the identified mutations for female fertility and growth traits. Results: Using a combination of bioinformatics and molecular assay technology, twelve non-synonymous SNPs in eleven genes were genotyped in a cattle population. Three and nine SNPs explained more than 1% of the additive genetic variance for percentage of normal sperm and scrotal circumference, respectively. The SNPs that had a major influence in percentage of normal sperm were mapped to LOC100138021 and TAF7L genes; and in TEX11 and AR genes for scrotal circumference. One SNP in TEX11 was explained similar to 13% of the additive genetic variance for scrotal circumference at 12 months. The tested SNP were also associated with weight measurements, but not with female fertility traits. Conclusions: The strong association of SNPs located in X chromosome genes with male fertility traits validates the QTL. The implicated genes became good candidates to be used for genetic evaluation, without detrimentally influencing female fertility traits. (AU)

Processo FAPESP: 13/12851-5 - Expressão gênica para estudar a puberdade e a fertilidade em bovinos da raça Brahman
Beneficiário:Gregório Miguel Ferreira de Camargo
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado