The Relationship of Fat Distribution and Insulin Resistance with Lumbar Spine Bone Mass in Women

Autor(es)

de Paula, Francisco J. A. ^[1] ; de Araujo, Iana M. ^[1] ; Carvalho, Adriana L. ^[1] ; Elias, Jr., Jorge ^[1] ; Salmon, Carlos E. G. ^[2] ; Nogueira-Barbosa, Marcello H. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Ribeirao Preto - Brazil

^[2] Univ Sao Paulo, Fac Philosophy Sci & Arts Ribeirao Preto, Dept Phys, Ribeirao Preto - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 10, n. 6 JUN 11 2015.
• Citações Web of Science: 20

Resumo

Bone marrow harbors a significant amount of body adipose tissue (BMAT). While BMAT might be a source of energy for bone modeling and remodeling, its increment can also represent impairment of osteoblast differentiation. The relationship between BMAT, bone mass and insulin sensitivity is only partially understood and seems to depend on the circumstances. The present study was designed to assess the association of BMAT with bone mineral density in the lumbar spine as well as with visceral adipose tissue, intrahepatic lipids, HOMA-IR, and serum levels of insulin and glucose. This cross-sectional clinical investigation included 31 non-diabetic women, but 11 had a pre-diabetes status. Dual X-ray energy absorptiometry was used to measure bone mineral density and magnetic resonance imaging was used to assess fat deposition in BMAT, visceral adipose tissue and liver. Our results suggest that in non-diabetic, there is an inverse relationship between bone mineral density in lumbar spine and BMAT and a trend persists after adjustment for weight, age, BMI and height. While there is a positive association between visceral adipose tissue and intrahepatic lipids with serum insulin levels, there is no association between BMAT and serum levels of insulin. Conversely, a positive relationship was observed between BMAT and serum glucose levels, whereas this association was not observed with other fat deposits. These relationships did not apply after adjustment for body weight, BMI, height and age. The present study shows that in a group of predominantly non-obese women the association between insulin resistance and BMAT is not an early event, as occurs with visceral adipose tissue and intrahepatic lipids. On the other hand, BMAT has a negative relationship with bone mineral density. Taken together, the results support the view that bone has a complex and non-linear relationship with energy metabolism. (AU)

• Processo FAPESP: 12/09527-9 - Valor Preditivo da Quantificação de Adiposidade Visceral e Óssea sobre Densidade Mineral Óssea e Ocorrência de Fratura no Diabetes Mellitus tipo 2
• Beneficiário: Iana Mizumukai de Araujo
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 12/14603-6 - Valor preditivo da quantificação de adiposidade visceral e óssea sobre densidade mineral óssea e ocorrência de fratura no Diabetes Mellitus tipo 2
• Beneficiário: Francisco José Albuquerque de Paula
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/09853-6 - Relação da Adiposidade Visceral, Hepática e Óssea com a Densidade Mineral Óssea e Ocorrência de Fratura no Diabetes Melito tipo 1.
• Beneficiário: Adriana Lelis Carvalho
• Modalidade de apoio: Bolsas no Brasil - Doutorado