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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Relationship of Fat Distribution and Insulin Resistance with Lumbar Spine Bone Mass in Women

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Author(s):
de Paula, Francisco J. A. [1] ; de Araujo, Iana M. [1] ; Carvalho, Adriana L. [1] ; Elias, Jr., Jorge [1] ; Salmon, Carlos E. G. [2] ; Nogueira-Barbosa, Marcello H. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Ribeirao Preto - Brazil
[2] Univ Sao Paulo, Fac Philosophy Sci & Arts Ribeirao Preto, Dept Phys, Ribeirao Preto - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PLoS One; v. 10, n. 6 JUN 11 2015.
Web of Science Citations: 20
Abstract

Bone marrow harbors a significant amount of body adipose tissue (BMAT). While BMAT might be a source of energy for bone modeling and remodeling, its increment can also represent impairment of osteoblast differentiation. The relationship between BMAT, bone mass and insulin sensitivity is only partially understood and seems to depend on the circumstances. The present study was designed to assess the association of BMAT with bone mineral density in the lumbar spine as well as with visceral adipose tissue, intrahepatic lipids, HOMA-IR, and serum levels of insulin and glucose. This cross-sectional clinical investigation included 31 non-diabetic women, but 11 had a pre-diabetes status. Dual X-ray energy absorptiometry was used to measure bone mineral density and magnetic resonance imaging was used to assess fat deposition in BMAT, visceral adipose tissue and liver. Our results suggest that in non-diabetic, there is an inverse relationship between bone mineral density in lumbar spine and BMAT and a trend persists after adjustment for weight, age, BMI and height. While there is a positive association between visceral adipose tissue and intrahepatic lipids with serum insulin levels, there is no association between BMAT and serum levels of insulin. Conversely, a positive relationship was observed between BMAT and serum glucose levels, whereas this association was not observed with other fat deposits. These relationships did not apply after adjustment for body weight, BMI, height and age. The present study shows that in a group of predominantly non-obese women the association between insulin resistance and BMAT is not an early event, as occurs with visceral adipose tissue and intrahepatic lipids. On the other hand, BMAT has a negative relationship with bone mineral density. Taken together, the results support the view that bone has a complex and non-linear relationship with energy metabolism. (AU)

FAPESP's process: 12/09527-9 - The role of bone marrow and visceral fat on bone mineral density and fracture occurrence in type 2 diabetes mellitus
Grantee:Iana Mizumukai de Araujo
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 12/14603-6 - The role of bone marrow and visceral fat on bone mineral density and fracture occurrence in type 2 Diabetes Mellitus
Grantee:Francisco José Albuquerque de Paula
Support Opportunities: Regular Research Grants
FAPESP's process: 13/09853-6 - Relationship between visceral, hepatic and bone adiposity with bone mineral density and fracture occurrence in type 1 diabetes mellitus.
Grantee:Adriana Lelis Carvalho
Support Opportunities: Scholarships in Brazil - Doctorate