The use of magnetic resonance imaging in the quantitative study of bone microarchitecture and its relatioship with the accumulation of muscle and bone marrow adipose tissue in type 2 diabetes mellitus

• Grant number: 18/14060-9
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2019
• End date: March 31, 2021
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Francisco José Albuquerque de Paula
• Grantee: Francisco José Albuquerque de Paula
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Bone fragility was recently recognized as an additional complication of type 2 diabetes mellitus (DM2). Bone mass in DM2 is normal or elevated when compared with a control group, and bone fragitily may be related with impairments in bone quality. Bone densitometry, even considered as a golden standard in the evaluation of bone density, does not reveal parameters related with bone quality. Thus, there is a need to explore other tools that could unveil fracture susceptibility in this condition. Magnetic resonance imaging (MRI) is a technique capable of quantifying bone marrow adipose tissue (MAT) and apparent trabecular volume (appTV). MAT is negatively related with bone mass in several disorders, such as anorexia nervosa and aging. In view that bone fragility in DM2 potentially impacts on morbidity and mortality, it is important to identify risk groups in order to prevent fractures. To that aim, exams like lumbar spine and muscle MRI spectroscopy, bone marrow adiposity measurements by spectroscopy, and MRI trabecular imaging in proximal tibia will be accomplished to elucidate the role of body fat distribution in bone mass parameters. Bone densitometry will be carried out to quantify bone mass and also body composition of patients and controls. The study also will investigate molecules originate in muscle and adipose tissue which may influence bone remodeling and marrow adipose tissue. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PARREIRAS-E-SILVA, LUCIANA T.; DE ARAUJO, IANA M.; ELIAS JR, JORGE; NOGUEIRA-BARBOSA, MARCELLO H.; SUEN, VIVIAN M. M.; MARCHINI, JULIO S.; SALMON, CARLOS E. G.; ALBUQUERQUE DE PAULA, FRANCISCO JOSE. Osteoporosis and Hepatic Steatosis: 2 Closely Related Complications in Short-Bowel Syndrome. Journal of Parenteral and Enteral Nutrition, FEB 2020. (18/14060-9, 16/18574-1)

DE ARAUJO, I. M.; PARREIRAS-E-SILVA, L. T.; CARVALHO, A. L.; ELIAS, JR., J.; SALMON, C. E. G.; DE PAULA, F. J. A.. Insulin resistance negatively affects bone quality not quantity: the relationship between bone and adipose tissue. OSTEOPOROSIS INTERNATIONAL, v. 31, n. 6, FEB 2020. (18/14060-9, 16/18574-1)

BATISTA, SERGIO LUCHINI; DE ARAUJO, IANA MIZUMUKAI; CARVALHO, ADRIANA LELIS; ALENCAR, MARIA AUGUSTA V. S. D.; NAHAS, ANDRESSA K.; ELIAS JR, JORGE; NOGUEIRA-BARBOSA, MARCELLO H.; SALMON, CARLOS E. G.; ELIAS, PAULA C. L.; MOREIRA, AYRTON C.; et al. Beyond the metabolic syndrome: Visceral and marrow adipose tissues impair bone quantity and quality in Cushing's disease. PLoS One, v. 14, n. 10, OCT 15 2019. (16/18574-1, 18/14060-9)

JAMILLY GOMES MACIEL; IANA MIZUMUKAI DE ARAÚJO; LUCIO C. TRAZZI; PAULO MAZZONCINI DE AZEVEDO-MARQUES; CARLOS ERNESTO GARRIDO SALMON; FRANCISCO JOSÉ ALBUQUERQUE DE PAULA; MARCELLO HENRIQUE NOGUEIRA-BARBOSA. Association of bone mineral density with bone texture attributes extracted using routine magnetic resonance imaging. Clinics, v. 75, 2020-08-26. (18/04266-9, 18/14060-9)

PARREIRAS-E-SILVA, LUCIANA T.; DE ARAUJO, IANA M.; ELIAS JR, JORGE; NOGUEIRA-BARBOSA, MARCELLO H.; SUEN, VIVIAN M. M.; MARCHINI, JULIO S.; SALMON, CARLOS E. G.; ALBUQUERQUE DE PAULA, FRANCISCO JOSE. Osteoporosis and Hepatic Steatosis: 2 Closely Related Complications in Short-Bowel Syndrome. Journal of Parenteral and Enteral Nutrition, v. 44, n. 7, p. 9-pg., 2020-02-12. (16/18574-1, 18/14060-9)

DE PAULA, FRANCISCO J. A.; ROSEN, CLIFFORD J.; NELSON, MT; WALSH, K. Marrow Adipocytes: Origin, Structure, and Function. ANNUAL REVIEW OF PHYSIOLOGY, VOL 82, v. 82, p. 24-pg., 2020-01-01. (18/14060-9)