Development and Characterization of a Hydrogel Containing Silver Sulfadiazine for Antimicrobial Topical Applications

Autor(es)

Jodar, Karin S. P. ^[1] ; Balcao, Victor M. ^{[2, 3, 1]} ; Chaud, Marco V. ^[1] ; Tubino, Matthieu ^[2] ; Yoshida, Valquiria M. H. ^[1] ; Oliveira, Jr., Jose M. ^[1] ; Vila, Marta M. D. C. ^{[2, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sorocaba, LaBNUS Biomat & Nanotechnol Lab, ibs2 Intelligent Biosensing & Biomol Stabilizat R, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Inst Chem, Campinas, SP - Brazil

^[3] Univ Minho, CEB Ctr Biol Engn, Braga - Portugal

• Tipo de documento: Artigo Científico
• Fonte: Journal of Pharmaceutical Sciences; v. 104, n. 7, p. 2241-2254, JUL 2015.
• Citações Web of Science: 15

Resumo

Development and optimization of a hydrogel with impregnated silver sulfadiazine was pursued, for antimicrobial topical applications. The selected hydrogel exhibited a homogeneous appearance, with whitish colloration and devoid of any fractures or cracks. The content in impregnated silver sulfadiazine was within established limits (1%, w/w) with a standard deviation of up to 1.28%. The hydrogel presented a good characteristic in relation to release of the active antimicrobial principle, verified through swelling tests and antimicrobial activity. The swelling tests indicated a higher increase in weight during the first 6 h of contact with a moist environment, with a maximum value of 266.00 +/- 0.81, and with maintenance of the original shape of the hydrogel. The impregnated silver sulfadiazine presented antimicrobial activity, as expected, indicating a prolonged release of the drug. The infrared spectra of the hydrogel with impregnated silver sulfadiazine indicated that the drug did not engage in any bonds with the polymeric matrix, which otherwise could have reduced its antimicrobial activity. The mechanical resistance tests produced good results, indicating that the hydrogels may be utilized in different locations of the human body with skin lesions. (c) 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:2241-2254, 2015 (AU)

• Processo FAPESP: 14/21122-0 - Uso de reserva técnica institucional para aquisição de equipamentos destinados à expansão da infraestrutura para os programas de pós-graduação da universidade de sorocaba - uniso
• Beneficiário: Norberto Aranha
• Modalidade de apoio: Auxílio à Pesquisa - Reserva Técnica para Infraestrutura Institucional de Pesquisa
• Processo FAPESP: 13/03181-6 - PneumoPhageKill: desenvolvimento de sistema terapêutico contendo bacteriófagos nanoencapsulados líticos para Pseudomonas aeruginosa, para tratamento de pneumonia bacteriana por aerossolização
• Beneficiário: Marta Maria Duarte Carvalho Vila
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/15651-4 - Tomógrafo para aplicações na área das Ciências Farmacêuticas
• Beneficiário: José Martins de Oliveira Junior
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