Development and Characterization of a Hydrogel Containing Silver Sulfadiazine for Antimicrobial Topical Applications

Author(s)

Jodar, Karin S. P. ^[1] ; Balcao, Victor M. ^{[2, 3, 1]} ; Chaud, Marco V. ^[1] ; Tubino, Matthieu ^[2] ; Yoshida, Valquiria M. H. ^[1] ; Oliveira, Jr., Jose M. ^[1] ; Vila, Marta M. D. C. ^{[2, 1]}

Affiliation

^[1] Univ Sorocaba, LaBNUS Biomat & Nanotechnol Lab, ibs2 Intelligent Biosensing & Biomol Stabilizat R, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Inst Chem, Campinas, SP - Brazil

^[3] Univ Minho, CEB Ctr Biol Engn, Braga - Portugal

• Document type: Journal article
• Source: Journal of Pharmaceutical Sciences; v. 104, n. 7, p. 2241-2254, JUL 2015.
• Web of Science Citations: 15

Abstract

Development and optimization of a hydrogel with impregnated silver sulfadiazine was pursued, for antimicrobial topical applications. The selected hydrogel exhibited a homogeneous appearance, with whitish colloration and devoid of any fractures or cracks. The content in impregnated silver sulfadiazine was within established limits (1%, w/w) with a standard deviation of up to 1.28%. The hydrogel presented a good characteristic in relation to release of the active antimicrobial principle, verified through swelling tests and antimicrobial activity. The swelling tests indicated a higher increase in weight during the first 6 h of contact with a moist environment, with a maximum value of 266.00 +/- 0.81, and with maintenance of the original shape of the hydrogel. The impregnated silver sulfadiazine presented antimicrobial activity, as expected, indicating a prolonged release of the drug. The infrared spectra of the hydrogel with impregnated silver sulfadiazine indicated that the drug did not engage in any bonds with the polymeric matrix, which otherwise could have reduced its antimicrobial activity. The mechanical resistance tests produced good results, indicating that the hydrogels may be utilized in different locations of the human body with skin lesions. (c) 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:2241-2254, 2015 (AU)

• FAPESP's process: 14/21122-0 - USE OF INSTITUTIONAL TECHNICAL RESERVE FOR PURCHASE OF EQUIPMENT DESIGNATED TO EXPANSION OF INFRASTRUCTURE FOR POST-GRADUATE PROGRAMS AT THE UNIVERSITY OF SOROCABA - UNISO
• Grantee: Norberto Aranha
• Support Opportunities: Research Grants - Technical Reserve for Institutional Research Infrastructure
• FAPESP's process: 13/03181-6 - PneumoPhageKill: development of a therapeutic system containing nanoencapsulated strictly lytic bacteriophages for Pseudomonas aeruginosa, for the treatment of bacterial pneumonia via nebulization
• Grantee: Marta Maria Duarte Carvalho Vila
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/15651-4 - Tomograph for applications in the area of Pharmaceutical Sciences
• Grantee: José Martins de Oliveira Junior
• Support Opportunities: Regular Research Grants