Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development and Characterization of a Hydrogel Containing Silver Sulfadiazine for Antimicrobial Topical Applications

Full text
Author(s):
Jodar, Karin S. P. [1] ; Balcao, Victor M. [2, 3, 1] ; Chaud, Marco V. [1] ; Tubino, Matthieu [2] ; Yoshida, Valquiria M. H. [1] ; Oliveira, Jr., Jose M. [1] ; Vila, Marta M. D. C. [2, 1]
Total Authors: 7
Affiliation:
[1] Univ Sorocaba, LaBNUS Biomat & Nanotechnol Lab, ibs2 Intelligent Biosensing & Biomol Stabilizat R, Sao Paulo - Brazil
[2] Univ Estadual Campinas, Inst Chem, Campinas, SP - Brazil
[3] Univ Minho, CEB Ctr Biol Engn, Braga - Portugal
Total Affiliations: 3
Document type: Journal article
Source: Journal of Pharmaceutical Sciences; v. 104, n. 7, p. 2241-2254, JUL 2015.
Web of Science Citations: 15
Abstract

Development and optimization of a hydrogel with impregnated silver sulfadiazine was pursued, for antimicrobial topical applications. The selected hydrogel exhibited a homogeneous appearance, with whitish colloration and devoid of any fractures or cracks. The content in impregnated silver sulfadiazine was within established limits (1%, w/w) with a standard deviation of up to 1.28%. The hydrogel presented a good characteristic in relation to release of the active antimicrobial principle, verified through swelling tests and antimicrobial activity. The swelling tests indicated a higher increase in weight during the first 6 h of contact with a moist environment, with a maximum value of 266.00 +/- 0.81, and with maintenance of the original shape of the hydrogel. The impregnated silver sulfadiazine presented antimicrobial activity, as expected, indicating a prolonged release of the drug. The infrared spectra of the hydrogel with impregnated silver sulfadiazine indicated that the drug did not engage in any bonds with the polymeric matrix, which otherwise could have reduced its antimicrobial activity. The mechanical resistance tests produced good results, indicating that the hydrogels may be utilized in different locations of the human body with skin lesions. (c) 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:2241-2254, 2015 (AU)

FAPESP's process: 13/03181-6 - PneumoPhageKill: development of a therapeutic system containing nanoencapsulated strictly lytic bacteriophages for Pseudomonas aeruginosa, for the treatment of bacterial pneumonia via nebulization
Grantee:Marta Maria Duarte Carvalho Vila
Support type: Regular Research Grants
FAPESP's process: 12/15651-4 - Tomograph for applications in the area of Pharmaceutical Sciences
Grantee:José Martins de Oliveira Junior
Support type: Regular Research Grants
FAPESP's process: 14/21122-0 - USE OF INSTITUTIONAL TECHNICAL RESERVE FOR PURCHASE OF EQUIPMENT DESIGNATED TO EXPANSION OF INFRASTRUCTURE FOR POST-GRADUATE PROGRAMS AT THE UNIVERSITY OF SOROCABA - UNISO
Grantee:Norberto Aranha
Support type: Research Grants - Technical Reserve for Institutional Research Infrastructure