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Synthesis, characterization and pharmacological applications of metal complexes with sulfadiazine

Grant number: 11/12875-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2011
Effective date (End): August 31, 2012
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Pedro Paulo Corbi
Grantee:Wesley Francisco Lino Jardim
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Metal complexes have been studied in diagnostic and treatment of human diseases. The use of platinum(II) complexes such as cisplatin and carboplatin on anticancer therapy is one of the best examples of application of inorganic compounds in medicine. Other examples are the uses of silver and gold complexes as antimicrobial and antiarthritic agents, respectively. The aim of this project is to synthesize, characterize and evaluate the biological activities of new metal complexes of gold(I), platinum(II) and palladium(II) with sulfadiazine.